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Macrophage metalloelastase

Summary

UniProt ID

Q63341

Gene Symbol

Mmel
Mmp12

Gene ID

117033

Organism

Rattus norvegicus (Norway rat)

External Links

PubChem: Q63341
Re-Glyco: Q63341

Annotation

Keyword

Calcium
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Repeat
Signal
Zinc
Zymogen

Gene Ontology (GO)

Displaying **all 4** entries
GO Term
extracellular space
nucleus
cytoplasm
extracellular matrix

Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Displaying entries **1 - 10** of 23 in total

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GO Term
positive regulation of transcription by RNA polymerase II
regulation of defense response to virus by host
elastin catabolic process
negative regulation of endothelial cell-matrix adhesion via fibronectin
negative regulation of transcription by RNA polymerase II
protein import into nucleus
response to xenobiotic stimulus
collagen catabolic process
positive regulation of interferon-alpha production
lung alveolus development

Displaying **all 6** entries
GO Term
zinc ion binding
metalloendopeptidase activity
collagen binding
sequence-specific DNA binding
core promoter sequence-specific DNA binding
calcium ion binding

Annotation information from UniProt.

Sequence

MKFLLVLVLLVSLQVSACGAAPMNESEFAEWYLSRFFDYQGDRIPMTKTKTNRNLLEEKLQEMQQFFGLEVTGQLDTSTLKIMHTSRCGVPDVQHLRAVPQRSRWMKRYLTYRIYNYTPDMKRADVDYIFQKAFQVWSDVTPLRFRKIHKGEADITILFAFGDHGDFYDFDGKGGTLAHAFYPGPGIQGDAHFDEAETWTKSFQGTNLFLVAVHELGHSLGLRHSNNPKSIMYPTYRYLHPNTFRLSADDIHSIQSLYGAPVKNPSLTNPGSPPSTVCHQSLSFDAVTTVGDKIFFFKDWFFWWRLPGSPATNITSISSMWPTIPSGIQAAYEIGGRNQLFLFKDEKYWLINNLVPEPHYPRSIHSLGFPASVKKIDAAVFDPLRQKVYFFVDKQYWRYDVRQELMDAAYPKLISTHFPGIRPKIDAVLYFKRHYYIFQGAYQLEYDPLLDRVTKTLSSTSWFGC

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
313	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Collagen degradation	Rattus norvegicus
Degradation of the extracellular matrix	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:13139	crescentic glomerulonephritis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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External Links

Annotation

International Collaboration

Acknowledgements