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NAD(+) hydrolase SARM1

Summary

UniProt ID

Q6PDS3

Gene Symbol

Kiaa0524
Sarm1

Gene ID

[237868]

Organism

Mus musculus (house mouse)

External Links

GlyGen: Q6PDS3
PubChem: Q6PDS3
The O-GlcNAc Database: Q6PDS3
Re-Glyco: Q6PDS3

Annotation

Keyword: Alternative splicing Cell projection Cytoplasm Differentiation Hydrolase Innate immunity Mitochondrion NAD Neurogenesis Phosphoprotein Reference proteome Repeat Synapse Transit peptide

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
signal transduction	IEA	GO_REF
nervous system development
response to glucose	IMP	PMID
NAD+ catabolic process	ISO	GO_REF
NAD+ catabolic process	IDA	PMID

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

innate immune response

cellular process [inference]

signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

catabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

organophosphate catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

nucleoside phosphate catabolic process [inference]

nucleotide catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

NAD+ metabolic process [inference]

NAD+ catabolic process

purine-containing compound catabolic process [inference]

purine nucleotide catabolic process [inference]

NAD+ catabolic process

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NAD+ metabolic process [inference]

NAD+ catabolic process

pyridine-containing compound catabolic process [inference]

pyridine nucleotide catabolic process [inference]

NAD+ catabolic process

cellular developmental process [inference]

cell differentiation

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell junction organization [inference]

synapse organization [inference]

modification of synaptic structure [inference]

modification of postsynaptic structure

multicellular organismal process [inference]

system process [inference]

nervous system process

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

cellular developmental process [inference]

cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to wounding [inference]

response to axon injury

immune response [inference]

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to chemical [inference]

response to oxygen-containing compound [inference]

response to carbohydrate [inference]

response to monosaccharide [inference]

response to hexose [inference]

response to glucose

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to mitochondrion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

regulation of innate immune response [inference]

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of dendrite morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of MyD88-independent toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of programmed cell death [inference]

regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of toll-like receptor signaling pathway [inference]

negative regulation of MyD88-independent toll-like receptor signaling pathway

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis

regulation of synapse organization [inference]

regulation of synapse pruning

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	Reference
cytoplasm	ISO	GO_REF
cytoplasm	IDA	PMID
cytoplasm	IEA	GO_REF GO_REF
mitochondrion	ISO	GO_REF
mitochondrion	EXP	PMID

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

membrane [inference]

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane [inference]

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane

cell junction [inference]

synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

mitochondrion

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

microtubule

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
NAD+ nucleosidase activity	ISO	GO_REF
NAD+ nucleosidase activity	IDA	PMID
NAD+ nucleosidase activity	IEA	GO_REF GO_REF
signaling adaptor activity	IEA	GO_REF
identical protein binding	ISO	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

binding [inference]

protein binding [inference]

identical protein binding

molecular adaptor activity [inference]

protein-macromolecule adaptor activity [inference]

signaling adaptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVLTLLFSAYKLCRFFTMSGPRPGADRLTVPGPDRSGGASPWWAAGGRGSREVSPGVGTEVQGALERSLPELQQALSELKQASAARAVGAGLAEVFQLVEEAWLLPAVGREVAQGLCDAIRLDGGLDLLLRLLQAPELETRVQAARLLEQILVAENRDRVARIGLGVILNLAKEREPVELARSVAGILEHMFKHSEETCQRLVAAGGLDAVLYWCRRTDPALLRHCALALANCALHGGQTVQRCMVEKRAAEWLFPLAFSKEDELLRLHACLAVAVLATNKEVEREVEHSGTLALVEPLVASLDPGRFARCLVDASDTSQGRGPDDLQSLVLLLDSSRLEAQCIGAFYLCAEAAIKSLQGKTKVFSDIGAIQSLKRLVSYSTNGTTSALAKRALRLLGEEVPRRILPCVASWKEAEVQTWLQQIGFSQYCENFREQQVDGDLLLRLTDEELQTDLGMKSSITRKRFFRELTELKTFASYATCDRSNLADWLGSLDPRFRQYTYGLVSCGLDRSLLHRVSEQQLLEDCGIRLGVHRTRILSAAREMLHSPLPCTGGKLSGDTPDVFISYRRNSGSQLASLLKVHLQLHGFSVFIDVEKLEAGKFEDKLIQSVIAARNFVLVLSAGALDKCMQDHDCKDWVHKEIVTALSCGKNIVPIIDGFEWPEPQALPEDMQAVLTFNGIKWSHEYQEATIEKIIRFLQGRPSQDSSAGSDTSLEGATPMGLP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
240		29187734 33300544 34418053	G49108TO	The O-GlcNAc Database
383			G14972EH	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE)	Mus musculus
IKK complex recruitment mediated by RIP1	Mus musculus
MyD88-independent TLR4 cascade	Mus musculus
TRAF6-mediated induction of TAK1 complex within TLR4 complex	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

International Collaboration

Acknowledgements