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Protein CASC3

Summary

UniProt ID: Q8K3W3
Gene Symbol: Casc3 Mln51
Gene ID: 192160
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q8K3W3
PubChem: Q8K3W3
The O-GlcNAc Database: Q8K3W3
O-GlcNAcAtlas: Q8K3W3
Re-Glyco: Q8K3W3

Annotation

Keyword: ADP-ribosylation Cell projection Coiled coil Cytoplasm Nonsense-mediated mRNA decay Nucleus Phosphoprotein RNA-binding Reference proteome Spliceosome Stress response Translation regulation Ubl conjugation mRNA transport

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	Reference
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
mRNA splicing, via spliceosome	ISS	GO_REF
mRNA splicing, via spliceosome	ISO	GO_REF
mRNA splicing, via spliceosome	IEA	GO_REF
mRNA export from nucleus	NAS	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

mRNA metabolic process [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

RNA processing [inference]

mRNA processing [inference]

mRNA splicing, via spliceosome

RNA splicing [inference]

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

localization [inference]

macromolecule localization [inference]

RNA localization [inference]

intracellular mRNA localization

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport [inference]

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

cellular localization [inference]

intracellular transport [inference]

nuclear transport [inference]

nucleocytoplasmic transport [inference]

nuclear export [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of catabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of protein metabolic process [inference]

regulation of translation

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

regulation of protein metabolic process [inference]

regulation of translation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process, nonsense-mediated decay

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	Reference
nucleus	ISO	GO_REF
nucleus	IDA	PMID
nucleus	IEA	GO_REF GO_REF
cytoplasm	ISO	GO_REF GO_REF
cytoplasm	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

U2-type catalytic step 1 spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

exon-exon junction complex

catalytic complex [inference]

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

ribonucleoprotein complex

spliceosomal complex [inference]

U2-type spliceosomal complex [inference]

U2-type catalytic step 1 spliceosome

catalytic step 1 spliceosome [inference]

U2-type catalytic step 1 spliceosome

cellular anatomical structure [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

nuclear membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

nuclear ribonucleoprotein granule [inference]

nuclear speck

perinuclear region of cytoplasm

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule [inference]

cytoplasmic stress granule

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
mRNA binding	IEA	GO_REF
enzyme binding	ISO	GO_REF
enzyme binding	IEA	GO_REF
ubiquitin protein ligase binding	ISO	GO_REF
ubiquitin protein ligase binding	IEA	GO_REF

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

mRNA binding

protein binding [inference]

enzyme binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

identical protein binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MADRRRQRASQDTEDEESGASGSDSGSPARGGGSCSGSVGGGGSGSLPSQRGGRGGGLHLRRVESGGAKSAEESECESEDGMEGDAVLSDYESAEDSEGEEDYSEEENSKVELKSEANDAADSSAKEKGEEKPESKGTVTGERQSGDGQESTEPVENKVGKKGPKHLDDDEDRKNPAYIPRKGLFFEHDLRGQTQEEEVRPKGRQRKLWKDEGRWEHDKFREDEQAPKSRQELIALYGYDIRSAHNPDDIKPRRIRKPRFGSSPQRDPNWIGDRSSKSHRHQGPGGNLPPRTFINRNTAGTGRMSASRNYSRSGGFKDGRTSFRPVEVAGQHGGRSAETLKHEASYRSRRLEQTPVRDPSPEPDAPLLGSPEKEEVASETPAAVPDITPPAPDRPIEKKSYSRARRTRTKVGDAVKAAEEVPPPSEGLASTATVPETTPAAKTGNWEAPVDSTTGGLEQDVAQLNIAEQSWSPSQPSFLQPRELRGVPNHIHMGAGPPPQFNRMEEMGVQSGRAKRYSSQRQRPVPEPPAPPVHISIMEGHYYDPLQFQGPIYTHGDSPAPLPPQGMIVQPEMHLPHPGLHPHQSPGPLPNPGLYPPPVSMSPGQPPPQQLLAPTYFSAPGVMNFGNPNYPYAPGALPPPPPPHLYPNTQAPPQVYGGVTYYNPAQQQVQPKPSPPRRTPQPVSIKPPPPEVVSRGSS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
694		36852467	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 4** entries
Pathway Name	Organism
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	Mus musculus
Transport of Mature mRNA derived from an Intron-Containing Transcript	Mus musculus
mRNA 3'-end processing	Mus musculus
pre-mRNA splicing	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

International Collaboration

Acknowledgements