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Potassium channel subfamily K member 2

Summary

UniProt ID: Q920B6
Gene Symbol: Kcnk2 Trek
Gene ID: 170899
Organism: Rattus norvegicus (Norway rat)

External Links

PubChem: Q920B6
Re-Glyco: Q920B6

Annotation

Keyword: Alternative splicing Cell membrane Cell projection Disulfide bond Endoplasmic reticulum Glycoprotein Ion channel Metal-binding Neurotransmitter transport Phosphoprotein Postsynaptic cell membrane Potassium Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	Reference
cardiac ventricle development	IEP	PMID
potassium ion transport	ISO	GO_REF
neurotransmitter transport
G protein-coupled receptor signaling pathway	ISO	GO_REF
memory	IEP	PMID

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

chemical synaptic transmission, postsynaptic

G protein-coupled receptor signaling pathway

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

export from cell [inference]

secretion by cell [inference]

glutamate secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

memory

chemical synaptic transmission, postsynaptic

behavior [inference]

learning or memory [inference]

memory

developmental process [inference]

anatomical structure development [inference]

cardiac chamber development [inference]

cardiac ventricle development

cochlea development

response to stimulus [inference]

response to stress [inference]

response to hypoxia [inference]

cellular response to hypoxia

response to wounding [inference]

response to axon injury

cellular response to stress [inference]

cellular response to hypoxia

response to external stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to abiotic stimulus [inference]

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to mechanical stimulus

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia [inference]

cellular response to hypoxia

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

response to chemical [inference]

response to lipid [inference]

response to fatty acid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

response to arachidonate [inference]

cellular response to arachidonate

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

response to oxygen-containing compound [inference]

response to fatty acid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

response to arachidonate [inference]

cellular response to arachidonate

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

detection of stimulus [inference]

detection of external stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of abiotic stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

detection of stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of touch

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to hypoxia

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

cellular response to oxygen levels [inference]

cellular response to decreased oxygen levels [inference]

cellular response to hypoxia

cellular response to oxygen-containing compound [inference]

cellular response to fatty acid [inference]

cellular response to arachidonate

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport

potassium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

neurotransmitter transport

amino acid transport [inference]

acidic amino acid transport [inference]

glutamate secretion

inorganic anion transport [inference]

chloride transport [inference]

chloride transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

glutamate secretion

secretion [inference]

secretion by cell [inference]

glutamate secretion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

potassium ion transmembrane transport

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

nitrogen compound transport [inference]

glutamate secretion

export from cell [inference]

secretion by cell [inference]

glutamate secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

regulation of growth [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular response to hypoxia

positive regulation of response to stimulus [inference]

positive regulation of cellular response to hypoxia

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of cellular response to hypoxia

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia [inference]

positive regulation of cellular response to hypoxia

regulation of developmental process [inference]

regulation of developmental growth [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of developmental process [inference]

negative regulation of developmental growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

chemical synaptic transmission, postsynaptic

G protein-coupled receptor signaling pathway

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of synaptic transmission, GABAergic

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

negative regulation of DNA biosynthetic process

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of DNA biosynthetic process [inference]

negative regulation of DNA biosynthetic process

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cellular response to hypoxia

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA biosynthetic process

regulation of cellular response to stress [inference]

regulation of cellular response to hypoxia [inference]

positive regulation of cellular response to hypoxia

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of organ growth [inference]

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of multicellular organismal development [inference]

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

negative regulation of cardiac muscle cell proliferation

negative regulation of heart growth [inference]

negative regulation of cardiac muscle tissue growth [inference]

negative regulation of cardiac muscle cell proliferation

regulation of biological quality [inference]

regulation of membrane potential

action potential [inference]

neuronal action potential

Displaying entries **1 - 5** of 27 in total

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GO Term	Evidence Code	Reference
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum membrane	EXP	PMID
endoplasmic reticulum membrane	IEA	GO_REF
plasma membrane	ISO	GO_REF
plasma membrane	EXP	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

voltage-gated potassium channel complex

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

transporter complex [inference]

transmembrane transporter complex [inference]

monoatomic ion channel complex [inference]

cation channel complex [inference]

potassium channel complex [inference]

voltage-gated potassium channel complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

sarcolemma

organelle membrane [inference]

endoplasmic reticulum membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse [inference]

Schaffer collateral - CA1 synapse

node of Ranvier

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

glial cell projection [inference]

astrocyte projection

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

calyx of Held

presynapse [inference]

axon terminus

calyx of Held

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GO Term	Evidence Code	Reference
voltage-gated potassium channel activity	ISO	GO_REF
outward rectifier potassium channel activity	ISO	GO_REF
outward rectifier potassium channel activity	IDA	PMID PMID PMID
potassium channel inhibitor activity	IDA	PMID
ligand-gated channel activity	ISO	GO_REF

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

metal ion transmembrane transporter activity [inference]

potassium ion transmembrane transporter activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

monoatomic cation channel activity [inference]

potassium channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

gated channel activity [inference]

mechanosensitive monoatomic ion channel activity [inference]

mechanosensitive monoatomic cation channel activity [inference]

mechanosensitive potassium channel activity

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity [inference]

voltage-gated monoatomic cation channel activity [inference]

voltage-gated potassium channel activity

outward rectifier potassium channel activity

ligand-gated channel activity

narrow pore channel activity [inference]

leak channel activity [inference]

potassium ion leak channel activity

binding [inference]

protein binding [inference]

identical protein binding

protein dimerization activity [inference]

protein heterodimerization activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

molecular function regulator activity [inference]

molecular function inhibitor activity [inference]

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

transporter regulator activity [inference]

channel regulator activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

ion channel regulator activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

potassium channel regulator activity [inference]

potassium channel inhibitor activity

transporter inhibitor activity [inference]

channel inhibitor activity [inference]

ion channel inhibitor activity [inference]

potassium channel inhibitor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MLASASRERPGYTAGVAAPDLLDPKSAAQNSKPRLSFSAKPTVLASRVESDSAINVMKWKTVSTIFLVVVLYLIIGATVFKALEQPQEISQRTTIVIQKQNFIAQHACVNSTELDELIQQIVTAINAGIIPLGNNSNQVSHWDLGSSFFFAGTVITTIGFGNISPRTEGGKIFCIIYALLGIPLFGFLLAGVGDQLGTIFGKGIAKVEDTFIKWNVSQTKIRIISTIIFILFGCVLFVALPAVIFKHIEGWSALDAIYFVVITLTTIGFGDYVAGGSDIEYLDFYKPVVWFWILVGLAYFAAVLSMIGDWLRVISKKTKEEVGEFRAHAAEWTANVTAEFKETRRRLSVEIYDKFQRATSVKRKLSAELAGNHNQELTPCRRTLSVNHLTSEREVLPPLLKAESIYLNGLTPHCAAEDIAVIENMK

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
110	N-linked (GlcNAc...) asparagine			UniProt
134	N-linked (GlcNAc...) asparagine			UniProt

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Phase 4 - resting membrane potential	Rattus norvegicus
TWIK related potassium channel (TREK)	Rattus norvegicus

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:224	transient cerebral ischemia	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements