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Peroxidasin homolog

Summary

UniProt ID: Q92626
Gene Symbol: KIAA0230 MG50 PRG2 PXD01 PXDN VPO VPO1
Gene ID: 7837
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0012448

GlyConnect

Peroxidasin homolog

GlyGen

Q92626

PubChem

Q92626

The Human Metabolome Database

HMDBP07959

Re-Glyco

Q92626

Annotation

Keyword: Alternative splicing Basement membrane Calcium Direct protein sequencing Disease variant Disulfide bond Endoplasmic reticulum Glycoprotein Heme Hydrogen peroxide Immunoglobulin domain Leucine-rich repeat Phosphoprotein Proteomics identification Reference proteome Repeat Signal

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
angiogenesis	IMP	PMID
eye development	IEA	GO_REF
immune response	NAS	PMID
response to oxidative stress	IEA	GO_REF
cell adhesion	ISS	GO_REF

GO Hierarchy

biological process

immune system process [inference]

immune response

cellular process [inference]

cell adhesion

metabolic process [inference]

catabolic process [inference]

hydrogen peroxide catabolic process

reactive oxygen species metabolic process [inference]

hydrogen peroxide metabolic process [inference]

hydrogen peroxide catabolic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

extracellular matrix assembly [inference]

basement membrane assembly

extracellular structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

external encapsulating structure organization [inference]

extracellular matrix organization

collagen fibril organization

basement membrane organization

basement membrane assembly

extracellular matrix assembly [inference]

basement membrane assembly

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

eye development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress

immune response

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
extracellular region	TAS	Reactome Reactome
extracellular region	IDA	PMID
basement membrane	ISS	GO_REF
basement membrane	IEA	GO_REF GO_REF
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

basement membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	Reference
peroxidase activity	IDA	PMID PMID
peroxidase activity	IBA	GO_REF
peroxidase activity	IEA	GO_REF
interleukin-1 receptor antagonist activity	NAS	PMID
extracellular matrix structural constituent	RCA	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on peroxide as acceptor

peroxidase activity

structural molecule activity [inference]

extracellular matrix structural constituent

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

cytokine receptor binding [inference]

interleukin-1 receptor antagonist activity

growth factor binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

cytokine binding [inference]

interleukin-1 binding [inference]

interleukin-1 receptor antagonist activity

laminin binding [inference]

laminin-1 binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

tetrapyrrole binding [inference]

heme binding

extracellular matrix binding [inference]

laminin binding [inference]

laminin-1 binding

antioxidant activity [inference]

peroxidase activity

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

molecular function inhibitor activity [inference]

signaling receptor inhibitor activity [inference]

receptor antagonist activity [inference]

interleukin-1 receptor antagonist activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAKRSRGPGRRCLLALVLFCAWGTLAVVAQKPGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQTSILDLRFNRIREIQPGAFRRLRNLNTLLLNNNQIKRIPSGAFEDLENLKYLYLYKNEIQSIDRQAFKGLASLEQLYLHFNQIETLDPDSFQHLPKLERLFLHNNRITHLVPGTFNHLESMKRLRLDSNTLHCDCEILWLADLLKTYAESGNAQAAAICEYPRRIQGRSVATITPEELNCERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLMIQNTQETDQGIYQCMAKNVAGEVKTQEVTLRYFGSPARPTFVIQPQNTEVLVGESVTLECSATGHPPPRISWTRGDRTPLPVDPRVNITPSGGLYIQNVVQGDSGEYACSATNNIDSVHATAFIIVQALPQFTVTPQDRVVIEGQTVDFQCEAKGNPPPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDTTVEVGANVQLPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGPADAGRYECVARNTIGSASVSMVLSVNVPDVSRNGDPFVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRYPRDPYTVEQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLNLIANLSGCTAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKSVYENGFNTPRGINPHRLYNGHALPMPRLVSTTLIGTETVTPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSDGQHCSNVCSNDPPCFSVMIPPNDSRARSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTEHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIATELLKLNPHWDGDTIYYETRKIVGAEIQHITYQHWLPKILGEVGMRTLGEYHGYDPGINAGIFNAFATAAFRFGHTLVNPLLYRLDENFQPIAQDHLPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRVPSQLLNTELTERLFSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAHTFEDLKNEIKNPEIREKLKRLYGSTLNIDLFPALVVEDLVPGSRLGPTLMCLLSTQFKRLRDGDRLWYENPGVFSPAQLTQIKQTSLARILCDNADNITRVQSDVFRVAEFPHGYGSCDEIPRVDLRVWQDCCEDCRTRGQFNAFSYHFRGRRSLEFSYQEDKPTKKTRPRKIPSVGRQGEHLSNSTSAFSTRSDASGTNDFREFVLEMQKTITDLRTQIKKLESRLSTTECVDAGGESHANNTKWKKDACTICECKDGQVTCFVEACPPATCAVPVNIPGACCPVCLQKRAEEKP

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

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Position	Description	PubMed ID	GlyTouCan ID	Source
392				GlyGen
424		30459171	G43417UB	GlyGen
640	N-linked (GlcNAc...) asparagine	23090970 24190977 25713063 29391424	G25418HZ	UniProt GlyGen GlyConnect
699	N-linked (GlcNAc...) asparagine	25713063		UniProt GlyGen
719	N-linked (GlcNAc...) asparagine	25713063		UniProt GlyGen
730		24190977		GlyGen
731	N-linked (GlcNAc...) asparagine	23090970 24190977 25713063 29741879 37074911	G01650EU G70101JE G80920RR G37399XV G82463GQ G14260UH G62765YT G64527OM G28541PG G05724UK G31852PQ G39446WN G41247ZX G02815KT G06110VR	UniProt GlyGen GlyConnect
865	N-linked (GlcNAc...) asparagine	25713063	G62765YT	UniProt GlyGen
964	N-linked (GlcNAc...) asparagine	29391424	G35107SO G11629QQ	UniProt GlyGen GlyConnect
1178	N-linked (GlcNAc...) asparagine	19159218 23090970 24190977 25713063 29391424 29741879 37074911	G55412XP G15169WU G57888GL G11629QQ G56784JY G47748JZ G22310AV G48414YA G87389XI G15664MX G84452RH G72747WU G73430PD G25079LO G48584BU G70101JE G80920RR G90659AW G62765YT G31852PQ G41247ZX G02815KT	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 2** entries
Pathway Name	Organism
Crosslinking of collagen fibrils	Homo sapiens
Regulation of MITF-M-dependent genes involved in extracellular matrix, focal adhesion and epithelial-to-mesenchymal transition	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080612	anterior segment dysgenesis 7	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements