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CCR4-NOT transcription complex subunit 6-like

Summary

UniProt ID: Q96LI5
Gene Symbol: CCR4B CNOT6L
Gene ID: 246175
Organism: Homo sapiens (human)

External Links

GlyGen: Q96LI5
PubChem: Q96LI5
The O-GlcNAc Database: Q96LI5
O-GlcNAcAtlas: Q96LI5
Re-Glyco: Q96LI5

Annotation

Keyword: 3D-structure Alternative splicing Cytoplasm Exonuclease Leucine-rich repeat Magnesium Metal-binding Nucleus Proteomics identification RNA-mediated gene silencing Reference proteome Repeat Transcription regulation Translation regulation mRNA processing

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	Reference
nuclear-transcribed mRNA poly(A) tail shortening	NAS	PMID
nuclear-transcribed mRNA poly(A) tail shortening	TAS	Reactome
nuclear-transcribed mRNA poly(A) tail shortening	IBA	GO_REF
nuclear-transcribed mRNA poly(A) tail shortening	IEA	GO_REF
mRNA processing

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA processing

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

mRNA metabolic process [inference]

mRNA processing

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

RNA processing [inference]

mRNA processing

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

regulation of protein metabolic process [inference]

regulation of translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

regulation of organelle assembly [inference]

regulation of cytoplasmic mRNA processing body assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

mRNA catabolic process [inference]

nuclear-transcribed mRNA catabolic process [inference]

nuclear-transcribed mRNA poly(A) tail shortening

regulatory ncRNA-mediated gene silencing

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

regulation of organelle assembly [inference]

regulation of cytoplasmic mRNA processing body assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of organelle assembly [inference]

positive regulation of cytoplasmic mRNA processing body assembly

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
nucleus	IDA	PMID
nucleus	IBA	GO_REF
nucleus	IEA	GO_REF
cytoplasm	EXP	PMID
cytoplasm	IDA	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

CCR4-NOT complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 5** entries
GO Term	Evidence Code	Reference
3'-5'-RNA exonuclease activity	IBA	GO_REF
poly(A)-specific ribonuclease activity	EXP	PMID PMID PMID
poly(A)-specific ribonuclease activity	TAS	Reactome
poly(A)-specific ribonuclease activity	IEA	GO_REF GO_REF GO_REF GO_REF
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

exonuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

exonuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

catalytic activity, acting on RNA [inference]

RNA nuclease activity [inference]

RNA exonuclease activity [inference]

RNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-RNA exonuclease activity

poly(A)-specific ribonuclease activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MRLIGMPKEKYDPPDPRRIYTIMSAEEVANGKKSHWAELEISGRVRSLSTSLWSLTHLTALHLNDNYLSRIPPDIAKLHNLVYLDLSSNKLRSLPAELGNMVSLRELLLNNNLLRVLPYELGRLFQLQTLGLKGNPLSQDILNLYQDPDGTRKLLNFMLDNLAVHPEQLPPRPWITLKERDQILPSASFTVMCYNVLCDKYATRQLYGYCPSWALNWEYRKKGIMEEIVNCDADIISLQEVETEQYFTLFLPALKERGYDGFFSPKSRAKIMSEQERKHVDGCAIFFKTEKFTLVQKHTVEFNQVAMANSDGSEAMLNRVMTKDNIGVAVVLEVHKELFGAGMKPIHAADKQLLIVANAHMHWDPEYSDVKLIQTMMFVSEVKNILEKASSRPGSPTADPNSIPLVLCADLNSLPDSGVVEYLSNGGVADNHKDFKELRYNECLMNFSCNGKNGSSEGRITHGFQLKSAYENNLMPYTNYTFDFKGVIDYIFYSKTHMNVLGVLGPLDPQWLVENNITGCPHPHIPSDHFSLLTQLELHPPLLPLVNGVHLPNRR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
468		29351928 40596516	G49108TO G70994MS	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Deadenylation of mRNA	Homo sapiens
M-decay: degradation of maternal mRNAs by maternally stored factors	Homo sapiens
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Acknowledgements