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M-decay: degradation of maternal mRNAs by maternally stored factors

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-9820841

PubChem

R-HSA-9820841

Description

Maternal transcripts are transcribed from the maternal genome and accumulate in the oocyte during oogenesis. A subset of these maternal transcripts is degraded during later development of the unfertilized oocyte and after fertilization of the oocyte. Maternal decay of maternal transcripts (M-decay, reviewed in Jian and Fan 2022) refers to the degradation of maternal transcripts by maternally provided factors such as ZFP36L2 (inferred from the mouse homolog in Chousal et al. 2018, Sha et al. 2018), BTG4 (inferred from the mouse homolog in Liu et al. 2016, Yu et al. 2016, Pasternak et al. 2016, Zhao et al. 2020), and AGO2 (inferred from the mouse homolog in Zhang et al. 2020). ZFP36L2 acting before fertilization and BTG4 acting after fertilization recruit the CCR4-NOT deadenylation complex to the mRNA to initiate degradation. AGO2 is primed with endogenous small interfering RNAs (endosiRNAs) produced from double-stranded RNAs that originate from specific loci. The resulting AGO2:endosiRNA complexes bind and hydrolyze complementary maternal mRNAs. Similar patterns of mRNA decay are observed in human and mouse zygotes (Sha et al. 2020).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 17 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
A5YKK6	CCR4-NOT transcription complex subunit 1	AD-005 CDC39 CNOT1 KIAA1007 NOT1	view
O75175	CCR4-NOT transcription complex subunit 3	CNOT3 KIAA0691 LENG2 NOT3	view
O95628	CCR4-NOT transcription complex subunit 4	CNOT4 NOT4	view
P06730	Eukaryotic translation initiation factor 4E	EIF4E EIF4EL1 EIF4F	view
P11940	Polyadenylate-binding protein 1	PAB1 PABP PABP1 PABPC1 PABPC2	view
P23588	Eukaryotic translation initiation factor 4B	EIF4B	view
P38919	Eukaryotic initiation factor 4A-III	DDX48 EIF4A3 KIAA0111	view
P47974	mRNA decay activator protein ZFP36L2	ERF2 RNF162C TIS11D ZFP36L2	view
P60842	Eukaryotic initiation factor 4A-I	DDX2A EIF4A EIF4A1	view
Q04637	Eukaryotic translation initiation factor 4 gamma 1	EIF4F EIF4G EIF4G1 EIF4GI	view

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