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Eukaryotic translation initiation factor 4B

Summary

UniProt ID: P23588
Gene Symbol: EIF4B
Gene ID: 1975
Organism: Homo sapiens (human)

External Links

GlyGen: P23588
PubChem: P23588
The O-GlcNAc Database: P23588
RaftProt: P23588
O-GlcNAcAtlas: P23588
Re-Glyco: P23588

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Direct protein sequencing Initiation factor Isopeptide bond Phosphoprotein Proteomics identification RNA-binding Reference proteome Ubl conjugation

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	Reference
formation of translation preinitiation complex
regulation of translational initiation	TAS	PMID
eukaryotic translation initiation factor 4F complex assembly

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

eukaryotic translation initiation factor 4F complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

eukaryotic translation initiation factor 4F complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

Displaying **all 2** entries
GO Term	Evidence Code	Reference
cytosol	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
eukaryotic translation initiation factor 4F complex	TAS	PMID

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical structure [inference]

cytosol

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
RNA binding	TAS	PMID
RNA binding	IEA	GO_REF
RNA binding	HDA	PMID PMID
translation initiation factor activity	TAS	PMID
RNA strand annealing activity

GO Hierarchy

molecular function

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

nucleic acid conformation isomerase activity [inference]

annealing activity [inference]

RNA strand annealing activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA strand annealing activity

annealing activity [inference]

RNA strand annealing activity

binding [inference]

nucleic acid binding [inference]

RNA binding

double-stranded RNA binding [inference]

RNA strand-exchange activity

single-stranded RNA binding [inference]

annealing activity [inference]

RNA strand annealing activity

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal small subunit binding

translation factor activity [inference]

translation initiation factor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MAASAKKKNKKGKTISLTDFLAEDGGTGGGSTYVSKPVSWADETDDLEGDVSTTWHSNDDDVYRAPPIDRSILPTAPRAAREPNIDRSRLPKSPPYTAFLGNLPYDVTEESIKEFFRGLNISAVRLPREPSNPERLKGFGYAEFEDLDSLLSALSLNEESLGNRRIRVDVADQAQDKDRDDRSFGRDRNRDSDKTDTDWRARPATDSFDDYPPRRGDDSFGDKYRDRYDSDRYRDGYRDGYRDGPRRDMDRYGGRDRYDDRGSRDYDRGYDSRIGSGRRAFGSGYRRDDDYRGGGDRYEDRYDRRDDRSWSSRDDYSRDDYRRDDRGPPQRPKLNLKPRSTPKEDDSSASTSQSTRAASIFGGAKPVDTAAREREVEERLQKEQEKLQRQLDEPKLERRPRERHPSWRSEETQERERSRTGSESSQTGTSTTSSRNARRRESEKSLENETLNKEEDCHSPTSKPPKPDQPLKVMPAPPPKENAWVKRSSNPPARSQSSDTEQQSPTSGGGKVAPAQPSEEGPGRKDENKVDGMNAPKGQTGNSSRGPGDGGNRDHWKESDRKDGKKDQDSRSAPEPKKPEENPASKFSSASKYAALSVDGEDENEGEDYAE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 15 in total

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Position	PubMed ID	GlyTouCan ID	Source
347	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	The O-GlcNAc Database
351		G49108TO	GlyGen
352	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
354	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
355	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
359	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database
409	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	The O-GlcNAc Database
425		G49108TO	GlyGen
433	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	The O-GlcNAc Database
495	29351928 30059200 30379171 30620550 31373491 31492838 32119511 33214551 33465208 34019948 34229054 34725712 35254053 37217939 38665916 39531497 40307207 40596516 40914422	G49108TO	GlyGen The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 9** entries
Pathway Name	Organism
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S	Homo sapiens
Deadenylation of mRNA	Homo sapiens
GTP hydrolysis and joining of the 60S ribosomal subunit	Homo sapiens
L13a-mediated translational silencing of Ceruloplasmin expression	Homo sapiens
M-decay: degradation of maternal mRNAs by maternally stored factors	Homo sapiens
Ribosomal scanning and start codon recognition	Homo sapiens
Translation initiation complex formation	Homo sapiens
Z-decay: degradation of maternal mRNAs by zygotically expressed factors	Homo sapiens
mTORC1-mediated signalling	Homo sapiens

Human Protein Atlas

ENSG00000063046

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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