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eukaryotic translation initiation factor 4B

Summary

Gene Symbol

EIF4B

Organism

Homo sapiens (human)

External Links

NCBI Gene

1975

PubChem

1975

Alliance of Genome Resources

HGNC:3285

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Direct protein sequencing
Initiation factor
Isopeptide bond
Phosphoprotein
Proteomics identification
RNA-binding
Reference proteome
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
P23588
B4DRM3
Q7Z5Y0
E7EX17

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
formation of translation preinitiation complex	IBA
regulation of translational initiation	TAS	2390971
eukaryotic translation initiation factor 4F complex assembly	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

eukaryotic translation initiation factor 4F complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

eukaryotic translation initiation factor 4F complex assembly

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

formation of translation preinitiation complex

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of nitrogen compound metabolic process [inference]

regulation of amide metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of translational initiation

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of translational initiation

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
cytosol	IDA
eukaryotic translation initiation factor 4F complex	TAS	2390971

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

RNA cap binding complex [inference]

eukaryotic translation initiation factor 4F complex

cellular anatomical entity [inference]

cytosol

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GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
translation initiation factor activity	IEA
protein binding	IPI	21044950 21887822 32814053
RNA strand annealing activity	IBA
RNA strand-exchange activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

protein-containing complex binding [inference]

ribonucleoprotein complex binding [inference]

ribosome binding [inference]

ribosomal small subunit binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

double-stranded RNA binding [inference]

RNA strand-exchange activity

single-stranded RNA binding [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

annealing activity [inference]

RNA strand annealing activity

translation regulator activity [inference]

translation regulator activity, nucleic acid binding [inference]

translation factor activity, RNA binding [inference]

translation initiation factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Eukaryotic translation initiation factor

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
RNA recognition motif domain
RNA-binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 74 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	1975	Xenbase:XB-GENE-988676
Mus musculus	75705	Xenbase:XB-GENE-988676	MOUSE16762
Danio rerio	336619		DANRE38951
Canis lupus familiaris	477600		CANLF10750
Bos taurus	505850		BOVIN29096
Danio rerio	553214		DANRE25062
Macaca mulatta	700688		MACMU05151
Pan troglodytes	737509		PANTR05778
Ornithorhynchus anatinus	100090195		ORNAN01836
Oryctolagus cuniculus	100354421		RABIT10380

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OrthoDB (Group)

International Collaboration

Acknowledgements