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Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

Summary

UniProt ID: Q96N66
Gene Symbol: BB1 LENG4 MBOAT7 OACT7
Gene ID: 79143
Organism: Homo sapiens (human)

External Links

GlyGen

Q96N66

PubChem

Q96N66

SwissLipids

SLP:000000131

The Human Metabolome Database

HMDBP11815

RaftProt

Q96N66

Re-Glyco

Q96N66

Annotation

Keyword: 3D-structure Acyltransferase Alternative splicing Disease variant Endoplasmic reticulum Glycoprotein Intellectual disability Phospholipid biosynthesis Proteomics identification Reference proteome Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	Reference
phosphatidylinositol biosynthetic process	IMP	PMID
phosphatidylinositol biosynthetic process	IBA	GO_REF
ventricular system development
layer formation in cerebral cortex	ISS	GO_REF
lipid modification	IBA	GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

phosphatidylinositol metabolic process [inference]

biosynthetic process [inference]

phosphatidylinositol biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

lipid modification

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine acyl-chain remodeling

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

layer formation in cerebral cortex

anatomical structure development [inference]

system development [inference]

ventricular system development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

regulation of triglyceride metabolic process

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GO Term	Evidence Code	Reference
endoplasmic reticulum	IDA	PMID
endoplasmic reticulum membrane	EXP	PMID PMID
endoplasmic reticulum membrane	TAS	Reactome Reactome
endoplasmic reticulum membrane	IEA	GO_REF
membrane	IBA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

organelle membrane contact site [inference]

mitochondria-associated endoplasmic reticulum membrane contact site

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GO Term	Evidence Code	Reference
1-acylglycerol-3-phosphate O-acyltransferase activity	TAS	Reactome
O-acyltransferase activity
2-acylglycerol-3-phosphate O-acyltransferase activity	TAS	Reactome
lysophospholipid acyltransferase activity	ISS	GO_REF
lysophospholipid acyltransferase activity	IBA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

O-acyltransferase activity

acylglycerol O-acyltransferase activity [inference]

1-acylglycerol-3-phosphate O-acyltransferase activity

2-acylglycerol-3-phosphate O-acyltransferase activity

lysophospholipid acyltransferase activity

lysophosphatidic acid acyltransferase activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MSPEEWTYLVVLLISIPIGFLFKKAGPGLKRWGAAAVGLGLTLFTCGPHTLHSLVTILGTWALIQAQPCSCHALALAWTFSYLLFFRALSLLGLPTPTPFTNAVQLLLTLKLVSLASEVQDLHLAQRKEMASGFSKGPTLGLLPDVPSLMETLSYSYCYVGIMTGPFFRYRTYLDWLEQPFPGAVPSLRPLLRRAWPAPLFGLLFLLSSHLFPLEAVREDAFYARPLPARLFYMIPVFFAFRMRFYVAWIAAECGCIAAGFGAYPVAAKARAGGGPTLQCPPPSSPEKAASLEYDYETIRNIDCYSTDFCVRVRDGMRYWNMTVQWWLAQYIYKSAPARSYVLRSAWTMLLSAYWHGLHPGYYLSFLTIPLCLAAEGRLESALRGRLSPGGQKAWDWVHWFLKMRAYDYMCMGFVLLSLADTLRYWASIYFCIHFLALAALGLGLALGGGSPSRRKAASQPTSLAPEKLREE

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
98				GlyGen
321	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
Acyl chain remodelling of PI	Homo sapiens

Disease

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081219	autosomal recessive intellectual developmental disorder 57	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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External Links

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International Collaboration

Acknowledgements