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Bile acid receptor

Summary

UniProt ID

Q96RI1

Gene Symbol

NR1H4
BAR
FXR
HRR1
RIP14

Organism

Homo sapiens (human)

Annotation

Keyword

3D-structure
Acetylation
Activator
Alternative promoter usage
Alternative splicing
DNA-binding
Disease variant
Inflammatory response
Innate immunity
Intrahepatic cholestasis
Isopeptide bond
Methylation
Nucleus
Phosphoprotein
Receptor
Reference proteome
Repressor
Transcription regulation
Ubl conjugation
Zinc-finger

Gene Ontology (GO)

Displaying entries **41 - 49** of 49 in total

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GO Term
negative regulation of tumor necrosis factor-mediated signaling pathway
negative regulation of very-low-density lipoprotein particle remodeling
regulation of low-density lipoprotein particle clearance
toll-like receptor 9 signaling pathway
intracellular triglyceride homeostasis
bile acid signaling pathway
intracellular bile acid receptor signaling pathway
negative regulation of monocyte chemotactic protein-1 production
positive regulation of phosphatidic acid biosynthetic process

Displaying **all 4** entries
GO Term
receptor complex
nucleoplasm
chromatin
euchromatin

Displaying entries **1 - 10** of 15 in total

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GO Term
bile acid binding
nuclear receptor binding
nuclear retinoid X receptor binding
transcription cis-regulatory region binding
RNA polymerase II transcription regulatory region sequence-specific DNA binding
DNA-binding transcription factor activity, RNA polymerase II-specific
DNA-binding transcription activator activity, RNA polymerase II-specific
DNA-binding transcription factor activity
nuclear receptor activity
sequence-specific DNA binding

Annotation information from UniProt.

Sequence

MVMQFQGLENPIQISPHCSCTPSGFFMEMMSMKPAKGVLTEQVAGPLGQNLEVEPYSQYSNVQFPQVQPQISSSSYYSNLGFYPQQPEEWYSPGIYELRRMPAETLYQGETEVAEMPVTKKPRMGASAGRIKGDELCVVCGDRASGYHYNALTCEGCKGFFRRSITKNAVYKCKNGGNCVMDMYMRRKCQECRLRKCKEMGMLAECMYTGLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKTELTPDQQTLLHFIMDSYNKQRMPQEITNKILKEEFSAEENFLILTEMATNHVQVLVEFTKKLPGFQTLDHEDQIALLKGSAVEAMFLRSAEIFNKKLPSGHSDLLEERIRNSGISDEYITPMFSFYKSIGELKMTQEEYALLTAIVILSPDRQYIKDREAVEKLQEPLLDVLQKLCKIHQPENPQHFACLLGRLTELRTFNHHHAEMLMSWRVNDHKFTPLLCEIWDVQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
			G49108TO	The O-GlcNAc Database

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Endogenous sterols	Homo sapiens
PPARA activates gene expression	Homo sapiens
Recycling of bile acids and salts	Homo sapiens
Synthesis of bile acids and bile salts	Homo sapiens
Synthesis of bile acids and bile salts via 27-hydroxycholesterol	Homo sapiens
Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol	Homo sapiens