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Hephaestin

Summary

UniProt ID

Q9BQS7

Gene Symbol

HEPH
KIAA0698
UNQ2562/PRO6242

Gene ID

[9843]

Organism

Homo sapiens (human)

External Links

GlyGen: Q9BQS7
PubChem: Q9BQS7
The Human Metabolome Database: HMDBP08247
RaftProt: Q9BQS7
Re-Glyco: Q9BQS7

Annotation

Keyword: Alternative splicing Calcium Cell membrane Disulfide bond Glycoprotein Iron transport Metal-binding Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Repeat Signal Sodium Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
iron ion transport
multicellular organismal-level iron ion homeostasis	ISS	GO_REF
multicellular organismal-level iron ion homeostasis	IEA	GO_REF
intestinal iron absorption	ISS	GO_REF
intestinal iron absorption	IEA	GO_REF

GO Hierarchy

biological process

multicellular organismal process [inference]

system process [inference]

digestive system process [inference]

intestinal absorption [inference]

intestinal iron absorption

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

monoatomic cation homeostasis [inference]

multicellular organismal-level iron ion homeostasis

inorganic ion homeostasis [inference]

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

transition metal ion transport [inference]

iron ion transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of iron ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transport [inference]

positive regulation of iron ion transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic ion transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of monoatomic cation transmembrane transport [inference]

regulation of iron ion transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

regulation of iron export across plasma membrane [inference]

positive regulation of iron export across plasma membrane

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of monoatomic ion transmembrane transport [inference]

positive regulation of cation transmembrane transport [inference]

positive regulation of iron ion transmembrane transport [inference]

positive regulation of iron export across plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome
plasma membrane	IBA	GO_REF
basolateral plasma membrane	IDA	PMID PMID
basolateral plasma membrane	IEA	GO_REF
perinuclear region of cytoplasm	IEA	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	Reference
ferroxidase activity	IDA	PMID
ferroxidase activity	IBA	GO_REF
ferroxidase activity	IEA	GO_REF GO_REF GO_REF GO_REF
copper ion binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor [inference]

ferroxidase activity

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MESGHLLWALLFMQSLWPQLTDGATRVYYLGIRDVQWNYAPKGRNVITNQPLDSDIVASSFLKSDKNRIGGTYKKTIYKEYKDDSYTDEVAQPAWLGFLGPVLQAEVGDVILIHLKNFATRPYTIHPHGVFYEKDSEGSLYPDGSSGPLKADDSVPPGGSHIYNWTIPEGHAPTDADPACLTWIYHSHVDAPRDIATGLIGPLITCKRGALDGNSPPQRQDVDHDFFLLFSVVDENLSWHLNENIATYCSDPASVDKEDETFQESNRMHAINGFVFGNLPELNMCAQKRVAWHLFGMGNEIDVHTAFFHGQMLTTRGHHTDVANIFPATFVTAEMVPWEPGTWLISCQVNSHFRDGMQALYKVKSCSMAPPVDLLTGKVRQYFIEAHEIQWDYGPMGHDGSTGKNLREPGSISDKFFQKSSSRIGGTYWKVRYEAFQDETFQEKMHLEEDRHLGILGPVIRAEVGDTIQVVFYNRASQPFSMQPHGVFYEKDYEGTVYNDGSSYPGLVAKPFEKVTYRWTVPPHAGPTAQDPACLTWMYFSAADPIRDTNSGLVGPLLVCRAGALGADGKQKGVDKEFFLLFTVLDENKSWYSNANQAAAMLDFRLLSEDIEGFQDSNRMHAINGFLFSNLPRLDMCKGDTVAWHLLGLGTETDVHGVMFQGNTVQLQGMRKGAAMLFPHTFVMAIMQPDNLGTFEIYCQAGSHREAGMRAIYNVSQCPGHQATPRQRYQAARIYYIMAEEVEWDYCPDRSWEREWHNQSEKDSYGYIFLSNKDGLLGSRYKKAVFREYTDGTFRIPRPRTGPEEHLGILGPLIKGEVGDILTVVFKNNASRPYSVHAHGVLESTTVWPLAAEPGEVVTYQWNIPERSGPGPNDSACVSWIYYSAVDPIKDMYSGLVGPLAICQKGILEPHGGRSDMDREFALLFLIFDENKSWYLEENVATHGSQDPGSINLQDETFLESNKMHAINGKLYANLRGLTMYQGERVAWYMLAMGQDVDLHTIHFHAESFLYRNGENYRADVVDLFPGTFEVVEMVASNPGTWLMHCHVTDHVHAGMETLFTVFSRTEHLSPLTVITKETEKAVPPRDIEEGNVKMLGMQIPIKNVEMLASVLVAISVTLLLVVLALGGVVWYQHRQRKLRRNRRSILDDSFKLLSFKQ

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 13 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
164	N-linked (GlcNAc...) asparagine			UniProt GlyGen
236	N-linked (GlcNAc...) asparagine			UniProt GlyGen
588	N-linked (GlcNAc...) asparagine			UniProt GlyGen
714	N-linked (GlcNAc...) asparagine			UniProt GlyGen
758	N-linked (GlcNAc...) asparagine	37074911	G83460ZZ G80920RR	UniProt GlyGen
829	N-linked (GlcNAc...) asparagine			UniProt GlyGen
873	N-linked (GlcNAc...) asparagine			UniProt GlyGen
931	N-linked (GlcNAc...) asparagine			UniProt GlyGen
1066		23584533	G57321FI	GlyGen
1070		23584533 25813380	G57321FI	GlyGen