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Iron uptake and transport

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-917937

PubChem

R-HSA-917937

Description

The transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell via the main path (by transferrin endocytosis), its goal is not the (still elusive) chelated iron pool in the cytosol nor the lysosomes but the mitochondria, where heme is synthesized and iron-sulfur clusters are assembled (Kurz et al,2008, Hower et al 2009, Richardson et al 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 16 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00450	Ceruloplasmin	CP hCG_1781201	view
P02787	Serotransferrin	PRO1400 TF	view
P02794	Ferritin heavy chain	FTH FTH1 FTHL6 OK/SW-cl.84 PIG15	view
P21399	Cytoplasmic aconitate hydratase	ACO1 IREB1	view
P30519	Heme oxygenase 2	HMOX2 HO2	view
P48200	Iron-responsive element-binding protein 2	IREB2	view
P49281	Natural resistance-associated macrophage protein 2	DCT1 DMT1 NRAMP2 OK/SW-cl.20 SLC11A2	view
P62979	Ubiquitin-ribosomal protein eS31 fusion protein	RPS27A UBA80 UBCEP1	view
P62987	Ubiquitin-ribosomal protein eL40 fusion protein	UBA52 UBCEP2	view
P80188	Neutrophil gelatinase-associated lipocalin	HNL LCN2 NGAL	view

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