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Ceruloplasmin

Summary

UniProt ID: P00450
Gene Symbol: CP hCG_1781201
Gene ID: 1356
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011270

GlyConnect

Ceruloplasmin

GlyGen

P00450

PubChem

P00450

The Human Metabolome Database

HMDBP00472

RaftProt

P00450

Re-Glyco

P00450

Annotation

Keyword: 3D-structure Direct protein sequencing Disulfide bond Glycoprotein Metal-binding Oxidoreductase Phosphoprotein Proteomics identification Reference proteome Repeat Secreted Signal

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	Reference
intracellular copper ion homeostasis	IDA	PMID
intracellular iron ion homeostasis	TAS	PMID Reactome
intracellular iron ion homeostasis	IDA	PMID
intracellular iron ion homeostasis	IMP	PMID PMID

GO Hierarchy

biological process

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

copper ion homeostasis [inference]

intracellular copper ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

copper ion homeostasis [inference]

intracellular copper ion homeostasis

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	Reference
extracellular region	NAS	PMID
extracellular region	TAS	PMID Reactome Reactome Reactome Reactome
extracellular region	IDA	PMID PMID
extracellular region	IEA	GO_REF GO_REF
extracellular region	HDA	PMID PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

blood microparticle

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	Reference
ferroxidase activity	EXP	PMID PMID
ferroxidase activity	TAS	PMID Reactome
ferroxidase activity	IDA	PMID
ferroxidase activity	IMP	PMID PMID
ferroxidase activity	IEA	GO_REF GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity

oxidoreductase activity, acting on peroxide as acceptor [inference]

peroxidase activity [inference]

oxidoreductase activity, acting on metal ions [inference]

oxidoreductase activity, acting on metal ions, oxygen as acceptor

ferroxidase activity

binding [inference]

protein binding [inference]

protein-folding chaperone binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

copper ion binding

antioxidant activity [inference]

peroxidase activity [inference]

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKILILGIFLFLCSTPAWAKEKHYYIGIIETTWDYASDHGEKKLISVDTEHSNIYLQNGPDRIGRLYKKALYLQYTDETFRTTIEKPVWLGFLGPIIKAETGDKVYVHLKNLASRPYTFHSHGITYYKEHEGAIYPDNTTDFQRADDKVYPGEQYTYMLLATEEQSPGEGDGNCVTRIYHSHIDAPKDIASGLIGPLIICKKDSLDKEKEKHIDREFVVMFSVVDENFSWYLEDNIKTYCSEPEKVDKDNEDFQESNRMYSVNGYTFGSLPGLSMCAEDRVKWYLFGMGNEVDVHAAFFHGQALTNKNYRIDTINLFPATLFDAYMVAQNPGEWMLSCQNLNHLKAGLQAFFQVQECNKSSSKDNIRGKHVRHYYIAAEEIIWNYAPSGIDIFTKENLTAPGSDSAVFFEQGTTRIGGSYKKLVYREYTDASFTNRKERGPEEEHLGILGPVIWAEVGDTIRVTFHNKGAYPLSIEPIGVRFNKNNEGTYYSPNYNPQSRSVPPSASHVAPTETFTYEWTVPKEVGPTNADPVCLAKMYYSAVEPTKDIFTGLIGPMKICKKGSLHANGRQKDVDKEFYLFPTVFDENESLLLEDNIRMFTTAPDQVDKEDEDFQESNKMHSMNGFMYGNQPGLTMCKGDSVVWYLFSAGNEADVHGIYFSGNTYLWRGERRDTANLFPQTSLTLHMWPDTEGTFNVECLTTDHYTGGMKQKYTVNQCRRQSEDSTFYLGERTYYIAAVEVEWDYSPQREWEKELHHLQEQNVSNAFLDKGEFYIGSKYKKVVYRQYTDSTFRVPVERKAEEEHLGILGPQLHADVGDKVKIIFKNMATRPYSIHAHGVQTESSTVTPTLPGETLTYVWKIPERSGAGTEDSACIPWAYYSTVDQVKDLYSGLIGPLIVCRRPYLKVFNPRRKLEFALLFLVFDENESWYLDDNIKTYSDHPEKVNKDDEEFIESNKMHAINGRMFGNLQGLTMHVGDEVNWYLMGMGNEIDLHTVHFHGHSFQYKHRGVYSSDVFDIFPGTYQTLEMFPRTPGIWLLHCHVTDHIHAGMETTYTVLQNEDTKSG

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying entries **1 - 10** of 16 in total

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Position	Description	PubMed ID	GlyTouCan ID	Source
129		28035807	G57321FI	GlyGen
138	N-linked (GlcNAc...) (complex) asparagine	14760718 15084671 16321355 16335952 17242517 18514042 19139490 19159218 19838169 23090970 23843990 24190977 24279413 24530628 24841998 29391424 29427759 29671580 29741879 30237853 32125861 34725484 37074911 7096333 7451505	G53075ES G69834CE G95678HJ G11115RO G39595FH G41044JW G65414LI G12793SR G99679NM G56518TU G76417NN G15169WU G70232NH G94917XT G37818NZ G70888PK G06247RL G47518TP G66665YI G89877QI G80075MS G11629QQ G57776ZS G72580QS G85144OK G77669RF G60834IK G03596YS G86795LJ G86880BF G27947YN G52527GH G90382BL G63980BQ G04854VP G26915XM G94470IW G87123QX G79666IR G81263BG G86752LQ G92135MA G98611JV G34989PA G81198YO G40834TG G43669FQ G07799LX G51413EV G08146BT G22310AV G45395BF G56749GV G74772YG G88374WZ G59324HL G07246CJ G20706XG G10819WX G40926MX G59536GA G14972EH G43223CG G26330YA G40574BA G82830MN G78787DI G05933EN G08918WF G47737VJ G71146HJ G75983OB G00912UN G42358LZ G48414YA G84467IZ G27915IV G11911BT G92551JA G61256FT G70441OD G70822IO G87661QW G83646BJ G17208MA G76295SF G15664MX G27126ED G04657PL G08293MJ G27058EU G45495MK G84452RH G83460ZZ G96091TT G37509XX G70223PD G60033FS G41071NU G86182NS G72747WU G70619PT G06356OH G37868ZX G59626AS G08290VR G01650EU G80920RR G63041LO G01485JJ G42124LM G23863VK G31118FR G83555HU G90659AW G77547TA G31916IQ G45504EY G37399XV G83633GK G62765YT G11870QZ G47644PP G72791KH G88891KO G95177YH G10486CT G22140GZ G50045TK G05049YU G28541PG G18647XP G85269DF G95865ZB G31852PQ G90575OW G72787SB G23719VF G39446WN G11314AS G22572EH G41247ZX G50282JC G35029YA G57776ZU G36379GD G02815KT G57317CE G92275SC	GlycoProtDB UniProt GlyGen GlyConnect
358	N-linked (GlcNAc...) (complex) asparagine	16321355 16335952 19139490 19159218 19838169 23090970 24190977 24279413 24530628 29671580 29741879 30237853 32125861 34725484 37074911 7096333 7451505	G56518TU G15169WU G70232NH G94917XT G69521XL G14547CB G81124ET G70888PK G92081HT G06247RL G47518TP G66665YI G89877QI G80075MS G57776ZS G72580QS G68490OW G99668VU G60834IK G86880BF G27947YN G52527GH G90382BL G80479JV G85282JO G37692EO G04854VP G94470IW G79666IR G92135MA G81198YO G40834TG G02528FI G43669FQ G22310AV G45395BF G56749GV G88374WZ G59324HL G10819WX G40926MX G14972EH G43223CG G58954YZ G31986NC G26330YA G10846ZT G40574BA G82830MN G00273SJ G08918WF G47737VJ G71146HJ G75983OB G00912UN G42358LZ G48414YA G84467IZ G58087IP G89098OM G11911BT G44211QA G70441OD G87661QW G83646BJ G36442WJ G76295SF G15664MX G46691LC G27126ED G04657PL G08293MJ G27058EU G84452RH G51640FO G41071NU G46902YN G72747WU G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G80920RR G42124LM G23863VK G31118FR G83555HU G90659AW G45504EY G62765YT G11870QZ G47644PP G95177YH G10486CT G22140GZ G50045TK G85269DF G95865ZB G31852PQ G11314AS G22572EH G41247ZX G35029YA G57776ZU G57317CE G28681TP G72197KC	GlycoProtDB UniProt GlyGen GlyConnect
360		30237853	G46524LG	GlyGen GlyConnect
397	N-linked (GlcNAc...) (complex) asparagine	14760718 16321355 16335952 17242517 18514042 19139490 19159218 19838169 23090970 23843990 24190977 24279413 24530628 24841998 29391424 29427759 29671580 29741879 30237853 32125861 34725484 37074911 7096333 7451505	G88619MM G10019LZ G55412XP G56518TU G67895PX G23010ZW G15169WU G70232NH G94917XT G37818NZ G14547CB G70888PK G92081HT G33791AF G06247RL G47518TP G66665YI G89877QI G37881RL G80075MS G11629QQ G57776ZS G72580QS G85144OK G99668VU G77669RF G86880BF G27947YN G52527GH G90382BL G04854VP G94470IW G87123QX G79666IR G92135MA G47748JZ G40834TG G86500WE G51413EV G08146BT G22310AV G45395BF G56749GV G88374WZ G10819WX G59536GA G14972EH G43223CG G95977AE G37412TK G31986NC G26330YA G10846ZT G15038BD G40574BA G82830MN G00273SJ G08918WF G47737VJ G75983OB G00912UN G42358LZ G48414YA G84467IZ G89098OM G11911BT G76295SF G46691LC G27126ED G04657PL G08293MJ G27058EU G84452RH G96091TT G41071NU G46902YN G72747WU G42962KI G44215PV G70619PT G06356OH G37868ZX G59626AS G80920RR G90659AW G31916IQ G62765YT G47950XN G11870QZ G10486CT G22140GZ G50045TK G85269DF G95865ZB G31852PQ G23719VF G11314AS G41247ZX G57776ZU G02815KT G28681TP	GlycoProtDB UniProt GlyGen GlyConnect
485		23584533 28035807	G57321FI	GlyGen
489		30459171	G43417UB	GlyGen
492		23584533 30459171	G43417UB G57321FI	GlyGen
505		30459171	G43417UB	GlyGen
507		30459171	G43417UB	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Defective CP causes aceruloplasminemia (ACERULOP)	Homo sapiens
Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)	Homo sapiens
Iron uptake and transport	Homo sapiens
Metal ion SLC transporters	Homo sapiens
Post-translational protein phosphorylation	Homo sapiens
Regulation of IGF Activity by IGFBP	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0050711	aceruloplasminemia	Alliance of Genome Resources
DOID:1826	epilepsy	Alliance of Genome Resources
DOID:12119	hemosiderosis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements