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Asporin

Summary

UniProt ID: Q9BXN1
Gene Symbol: ASPN PLAP1 SLRR1C UNQ215/PRO241
Gene ID: 54829
Organism: Homo sapiens (human)

External Links

GlyConnect

Asporin

GlyGen

Q9BXN1

PubChem

Q9BXN1

The Human Metabolome Database

HMDBP14517

Re-Glyco

Q9BXN1

Annotation

Keyword: Biomineralization Calcium Direct protein sequencing Disulfide bond Extracellular matrix Glycoprotein Leucine-rich repeat Proteomics identification Reference proteome Repeat Signal Triplet repeat expansion

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
bone mineralization	IDA	PMID
negative regulation of transforming growth factor beta receptor signaling pathway	IDA	PMID
negative regulation of transforming growth factor beta receptor signaling pathway	IEA	GO_REF
negative regulation of tooth mineralization	ISS	GO_REF
negative regulation of tooth mineralization	IEA	GO_REF

GO Hierarchy

biological process

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

response to stimulus [inference]

response to chemical [inference]

response to fluoride

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of developmental process [inference]

negative regulation of biomineral tissue development [inference]

negative regulation of tooth mineralization

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of biomineral tissue development [inference]

negative regulation of tooth mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

negative regulation of biomineral tissue development [inference]

negative regulation of tooth mineralization

regulation of tooth mineralization [inference]

negative regulation of tooth mineralization

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

negative regulation of transforming growth factor beta receptor signaling pathway

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

negative regulation of biomineral tissue development [inference]

negative regulation of tooth mineralization

regulation of tooth mineralization [inference]

negative regulation of tooth mineralization

Displaying **all 5** entries
GO Term	Evidence Code	Reference
obsolete extracellular space
extracellular matrix	IDA	PMID
extracellular matrix	IEA	GO_REF
extracellular matrix	HDA	PMID PMID PMID PMID PMID
cell projection

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

cell projection

Displaying 1 entry
GO Term	Evidence Code	Reference
calcium ion binding	IDA	PMID

GO Hierarchy

molecular function

binding [inference]

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MKEYVLLLFLALCSAKPFFSPSHIALKNMMLKDMEDTDDDDDDDDDDDDDDEDNSLFPTREPRSHFFPFDLFPMCPFGCQCYSRVVHCSDLGLTSVPTNIPFDTRMLDLQNNKIKEIKENDFKGLTSLYGLILNNNKLTKIHPKAFLTTKKLRRLYLSHNQLSEIPLNLPKSLAELRIHENKVKKIQKDTFKGMNALHVLEMSANPLDNNGIEPGAFEGVTVFHIRIAEAKLTSVPKGLPPTLLELHLDYNKISTVELEDFKRYKELQRLGLGNNKITDIENGSLANIPRVREIHLENNKLKKIPSGLPELKYLQIIFLHSNSIARVGVNDFCPTVPKMKKSLYSAISLFNNPVKYWEMQPATFRCVLSRMSVQLGNFGM

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 3** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
55	O-linked (GalNAc...) serine	11152692		UniProt GlyGen
98		30459171	G43417UB	GlyGen
282	N-linked (GlcNAc...) asparagine	11152692 19159218 24190977 29741879 37074911	G05962QB G64394MX G35541EV G34617SM G93718GY G80075MS G11629QQ G57776ZS G68490OW G86795LJ G86880BF G90382BL G90093AU G02315DX G20528HD G24954UD G26915XM G94470IW G87123QX G79666IR G81263BG G65019XG G34989PA G81198YO G40834TG G22310AV G45395BF G85554PZ G10819WX G40926MX G14972EH G02030ZB G43223CG G10846ZT G40574BA G08918WF G58087IP G27915IV G89098OM G23505EP G92551JA G08110WX G61256FT G70441OD G72797UR G70822IO G87661QW G66760KM G83646BJ G17208MA G72667IM G76295SF G66621EA G46691LC G80223IX G25418HZ G27126ED G04657PL G25451PN G27058EU G84452RH G46524LG G83460ZZ G37509XX G51640FO G10488MI G82592ZH G60033FS G41071NU G91636VS G07755XJ G70418MS G86182NS G35253PZ G72747WU G44215PV G70619PT G06356OH G59626AS G08290VR G14994KB G92406TI G46503DX G20210JR G01650EU G80920RR G63041LO G01485JJ G50757KG G73968GN G65184UU G79568CQ G03382KH G42124LM G65092SV G23863VK G90659AW G74430RZ G77547TA G31916IQ G45504EY G64409MC G80333GO G47644PP G88891KO G72790NZ G10256JP G95177YH G10486CT G50045TK G05049YU G46687AB G90734RJ G28541PG G72787SB G23719VF G11314AS G35029YA G36379GD G02815KT G89045VA	UniProt GlyGen GlyConnect

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying 1 entry
Pathway Name	Organism
ECM proteoglycans	Homo sapiens

Disease

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:7147	ankylosing spondylitis	Alliance of Genome Resources
DOID:8398	osteoarthritis	Alliance of Genome Resources
DOID:90	degenerative disc disease	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements