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Serine hydroxymethyltransferase, mitochondrial

Summary

UniProt ID: Q9CZN7
Gene Symbol: Shmt2
Gene ID: 108037
Organism: Mus musculus (house mouse)

External Links

GlyGen: Q9CZN7
PubChem: Q9CZN7
Re-Glyco: Q9CZN7

Annotation

Keyword: Acetylation Alternative splicing Cytoplasm Mitochondrion inner membrane Mitochondrion nucleoid Nucleus One-carbon metabolism Phosphoprotein Pyridoxal phosphate Reference proteome Transferase Transit peptide

Gene Ontology (GO)

Displaying entries **1 - 5** of 39 in total

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GO Term	Evidence Code	Reference
regulation of oxidative phosphorylation	ISO	GO_REF
regulation of oxidative phosphorylation	IMP	PMID
regulation of oxidative phosphorylation	IEA	GO_REF
glycine metabolic process	ISS	GO_REF
glycine metabolic process	ISO	GO_REF GO_REF

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrahydrofolate interconversion

biosynthetic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

pteridine-containing compound metabolic process [inference]

folic acid-containing compound metabolic process [inference]

tetrahydrofolate metabolic process

tetrahydrofolate interconversion

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

primary metabolic process [inference]

amino acid metabolic process [inference]

amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

proteinogenic amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination [inference]

protein K63-linked deubiquitination

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

formate metabolic process [inference]

formate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

proteinogenic amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-serine metabolic process

L-serine biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid metabolic process [inference]

glycine metabolic process

glycine biosynthetic process

L-amino acid metabolic process [inference]

L-serine metabolic process

L-serine biosynthetic process

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

one-carbon metabolic process

tetrahydrofolate interconversion

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

formate biosynthetic process

proteinogenic amino acid biosynthetic process [inference]

alpha-amino acid biosynthetic process [inference]

serine family amino acid biosynthetic process [inference]

L-amino acid biosynthetic process [inference]

L-serine biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotetramerization

protein tetramerization

protein homotetramerization

response to stimulus [inference]

response to chemical [inference]

response to peptide [inference]

response to cytokine [inference]

response to type I interferon

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of generation of precursor metabolites and energy [inference]

regulation of cellular respiration [inference]

regulation of aerobic respiration

regulation of oxidative phosphorylation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of mitochondrial gene expression [inference]

regulation of mitochondrial translation

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of translation [inference]

regulation of mitochondrial translation

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

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GO Term	Evidence Code	Reference
nucleus	ISS	GO_REF
nucleus	ISO	GO_REF
nucleus	IDA	PMID
nucleus	IGI	PMID
nucleus	IEA	GO_REF GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

BRISC complex

cellular anatomical structure [inference]

cytoplasm

nucleoid [inference]

mitochondrial nucleoid

membrane [inference]

organelle membrane [inference]

organelle inner membrane [inference]

mitochondrial inner membrane

mitochondrial membrane [inference]

mitochondrial inner membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

cytoskeleton [inference]

microtubule cytoskeleton

mitochondrial nucleoid

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
chromatin binding	ISO	GO_REF
chromatin binding	IEA	GO_REF
glycine hydroxymethyltransferase activity	ISS	GO_REF
glycine hydroxymethyltransferase activity	ISO	GO_REF GO_REF
glycine hydroxymethyltransferase activity	IMP	PMID PMID

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring one-carbon groups [inference]

hydroxymethyl-, formyl- and related transferase activity [inference]

glycine hydroxymethyltransferase activity

lyase activity [inference]

carbon-carbon lyase activity [inference]

aldehyde-lyase activity [inference]

threonine aldolase activity [inference]

L-allo-threonine aldolase activity

binding [inference]

chromatin binding

protein binding [inference]

identical protein binding

amino acid binding

small molecule binding [inference]

vitamin binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

ion binding [inference]

anion binding [inference]

pyridoxal phosphate binding

heterocyclic compound binding [inference]

vitamin B6 binding [inference]

pyridoxal phosphate binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MVSFSLLRTTRPLQRCGQLVCMAARAQHSKVAQTQAGEAAGGWTGQESLSDSDPEMWELLQREKDRQCRGLELIASENFCSRAALEALGSCLNNKYSEGYPGKRYYGGAEVVDEIELLCQRRALEAFDLDPAQWGVNVQPYSGSPANLAAYTALLQPHDRIMGLDLPDGGHLTHGYMSDVKRISATSIFFESMPYKLNPQTGLIDYDQLALTARLFRPRLIIAGTSAYARLIDYARMREVCDEVRAHLLADMAHISGLVAAKVIPSPFKYADVVTTTTHKTLRGARSGLIFYRKGVRTVDPKTGKEIPYTFEDRINFAVFPSLQGGPHNHAIAAVAVALKQACTPMFREYSLQVLRNAQAMADALLKRGYSLVSGGTDTHLVLVDLRPKGLDGARAERVLELVSITANKNTCPGDRSAITPGGLRLGAPALTSRQFREDDFRRVVDFIDEGVNIGLEVKRKTAKLQDFKSFLLKDPETSQRLANLRQQVEQFARGFPMPGFDER

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites