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Disintegrin and metalloproteinase domain-containing protein 22

Summary

UniProt ID: Q9P0K1
Gene Symbol: ADAM22 MDC2
Gene ID: 53616
Organism: Homo sapiens (human)

External Links

GlyGen: Q9P0K1
PubChem: Q9P0K1
Re-Glyco: Q9P0K1

Annotation

Keyword: 3D-structure Alternative splicing Cell adhesion Cell membrane Cell projection Cleavage on pair of basic residues Disease variant Disulfide bond EGF-like domain Epilepsy Glycoprotein Phosphoprotein Proteomics identification Receptor Reference proteome Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	Reference
proteolysis	IBA	GO_REF
proteolysis	IEA	GO_REF
cell adhesion
negative regulation of cell adhesion	NAS	PMID
central nervous system development	TAS	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion

regulation of cellular process [inference]

regulation of cell communication [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

positive regulation of synaptic transmission

regulation of cell adhesion [inference]

negative regulation of cell adhesion

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of synaptic transmission

negative regulation of cellular process [inference]

negative regulation of cell adhesion

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome Reactome
plasma membrane	IDA	PMID
plasma membrane	IEA	GO_REF GO_REF
membrane	ISS	GO_REF
membrane	NAS	PMID

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

Displaying **all 4** entries
GO Term	Evidence Code	Reference
metalloendopeptidase activity	IBA	GO_REF
metalloendopeptidase activity	IEA	GO_REF
integrin binding	NAS	PMID
signaling receptor activity	ISS	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity [inference]

metalloendopeptidase activity

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

protein-containing complex binding [inference]

integrin binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MQAAVAVSVPFLLLCVLGTCPPARCGQAGDASLMELEKRKENRFVERQSIVPLRLIYRSGGEDESRHDALDTRVRGDLGGPQLTHVDQASFQVDAFGTSFILDVVLNHDLLSSEYIERHIEHGGKTVEVKGGEHCYYQGHIRGNPDSFVALSTCHGLHGMFYDGNHTYLIEPEENDTTQEDFHFHSVYKSRLFEFSLDDLPSEFQQVNITPSKFILKPRPKRSKRQLRRYPRNVEEETKYIELMIVNDHLMFKKHRLSVVHTNTYAKSVVNMADLIYKDQLKTRIVLVAMETWATDNKFAISENPLITLREFMKYRRDFIKEKSDAVHLFSGSQFESSRSGAAYIGGICSLLKGGGVNEFGKTDLMAVTLAQSLAHNIGIISDKRKLASGECKCEDTWSGCIMGDTGYYLPKKFTQCNIEEYHDFLNSGGGACLFNKPSKLLDPPECGNGFIETGEECDCGTPAECVLEGAECCKKCTLTQDSQCSDGLCCKKCKFQPMGTVCREAVNDCDIRETCSGNSSQCAPNIHKMDGYSCDGVQGICFGGRCKTRDRQCKYIWGQKVTASDKYCYEKLNIEGTEKGNCGKDKDTWIQCNKRDVLCGYLLCTNIGNIPRLGELDGEITSTLVVQQGRTLNCSGGHVKLEEDVDLGYVEDGTPCGPQMMCLEHRCLPVASFNFSTCLSSKEGTICSGNGVCSNELKCVCNRHWIGSDCNTYFPHNDDAKTGITLSGNGVAGTNIIIGIIAGTILVLALILGITAWGYKNYREQRQLPQGDYVKKPGDGDSFYSDIPPGVSTNSASSSKKRSNGLSHSWSERIPDTKHISDICENGRPRSNSWQGNLGGNKKKIRGKRFRPRSNSTETLSPAKSPSSSTGSIASSRKYPYPMPPLPDEDKKVNRQSARLWETSI

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 5** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
175	N-linked (GlcNAc...) asparagine			UniProt GlyGen
208		37074911	G20706XG G27126ED G04657PL G27058EU G02886BB G90659AW	GlyGen
519	N-linked (GlcNAc...) asparagine	19692335 24190977 37074911	G95865ZB G02815KT	UniProt GlyGen
634	N-linked (GlcNAc...) asparagine	19692335	G00912UN	UniProt GlyGen
675	N-linked (GlcNAc...) asparagine	19692335		UniProt GlyGen