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LGI-ADAM interactions

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-5682910

PubChem

R-HSA-5682910

Description

Synapse formation and maturation require multiple interactions between presynaptic and postsynaptic neurons. These interactions are mediated by a diverse set of synaptogenic proteins (Kegel et al. 2013, Siddiqui & Craig 2011). Initial synapse formation needs both the binding of secreted proteins to presynaptic and postsynaptic receptors, and the direct binding between presynaptic and postsynaptic transmembrane proteins. One class of molecules that plays an important role in cellular interactions in nervous system development and function is the leucine-rich glioma inactivated (LGI) protein family. These are secreted synaptogenic proteins consisting of an LRR (leucine-rich repeat) domain and a epilepsy-associated or EPTP (epitempin) domain (Gu et al. 2002). Both protein domains are generally involved in protein-protein interactions. Genetic and biochemical evidence suggests that the mechanism of action of LGI proteins involves binding to a subset of cell surface receptors belonging to the ADAM (a disintegrin and metalloproteinase) family, i.e. ADAM11, ADAM22 and ADAM23. These interactions play crucial role in the development and function of the vertebrate nervous system mainly mediating synaptic transmission and myelination (Kegel et al. 2013, Novak 2004, Seals & Courtneidge 2003).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 11 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O75077	Disintegrin and metalloproteinase domain-containing protein 23	ADAM23 MDC3	view
O75078	Disintegrin and metalloproteinase domain-containing protein 11	ADAM11 MDC	view
O95970	Leucine-rich glioma-inactivated protein 1	EPT LGI1 UNQ775/PRO1569	view
Q16623	Syntaxin-1A	STX1 STX1A	view
Q8N0V4	Leucine-rich repeat LGI family member 2	KIAA1916 LGI2 LGIL2	view
Q8N135	Leucine-rich repeat LGI family member 4	LGI4 LGIL3 UNQ6515/PRO21485	view
Q8N145	Leucine-rich repeat LGI family member 3	LGI3 LGIL4 UNQ8190/PRO23199	view
Q8WXS5	Voltage-dependent calcium channel gamma-8 subunit	CACNG6 CACNG8	view
Q9P0K1	Disintegrin and metalloproteinase domain-containing protein 22	ADAM22 MDC2	view
Q9UBN1	Voltage-dependent calcium channel gamma-4 subunit	CACNG4	view

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