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MIRAGE
Toll-like receptor 4
Summary
- UniProt ID
- Q9QX05
- Gene Symbol
-
- Tlr4
- Gene ID
- 29260
- Organism
- Rattus norvegicus (Norway rat)
Annotation
- Keyword
-
- Cell membrane
- Cell projection
- Disulfide bond
- Endosome
- Glycoprotein
- Inflammatory response
- Innate immunity
- Leucine-rich repeat
- NAD
- Receptor
- Reference proteome
- Repeat
- Signal
- Transmembrane helix
- Gene Ontology (GO)
| GO Term |
|---|
| cytoplasm |
| plasma membrane |
| receptor complex |
| early endosome |
| external side of plasma membrane |
| cell surface |
| perinuclear region of cytoplasm |
| ruffle |
| endosome membrane |
| phagocytic cup |
Sequence
MMPLLHLAGTLIMALFLSCLRPGSLNPCIEVLPNITYQCMDQNLSKIPHDIPYSTKNLDLSFNPLKILRSYSFTNFSQLQWLDLSRCEIETIEDKAWHGLNQLSTLVLTGNPIKSFSPGSFSGLTNLENLVAVETKMTSLEGFHIGQLISLKKLNVAHNLIHSFKLPEYFSNLTNLEHVDLSYNYIQTISVKDLQFLRENPQVNLSLDLSLNPIDSIQAQAFQGIRLHELTLRSNFNSSNVLKMCLQNMTGLHVHRLILGEFKNERNLESFDRSVMEGLCNVSIDEFRLTYINHFSDDIYNLNCLANISAMSFTGVHIKHIADVPRHFKWQSLSIIRCHLKPFPKLSLPFLKSWTLTTNREDISFGQLALPSLRYLDLSRNAMSFRGCCSYSDFGTNNLKYLDLSFNGVILMSANFMGLEELEYLDFQHSTLKKVTEFSVFLSLEKLLYLDISYTNTKIDFDGIFLGLISLNTLKMAGNSFKDNTLSNVFTNTTNLTFLDLSKCQLEQISRGVFDTLYRLQLLNMSHNNLLFLDPSHYKQLYSLRTLDCSFNRIETSKGILQHFPKSLAVFNLTNNSVACICEYQNFLQWVKDQKMFLVNVEQMKCASPIDMKASLVLDFTNSTCYIYKTIISVSVVSVLVVATVAFLIYHFYFHLILIAGCKKYSRGESIYDAFVIYSSQNEDWVRNELVKNLEEGVPRFQLCLHYRDFIPGVAIAANIIQEGFHKSRKVIVVVSRHFIQSRWCIFEYEIAQTWQFLSSRSGIIFIVLEKVEKSLLRQQVELYRLLSRNTYLEWEDNALGRHIFWRRLKKALLDGKALNPDETSEEEQEATTLT
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 34 | N-linked (GlcNAc...) asparagine |
|
||
| 43 | N-linked (GlcNAc...) asparagine |
|
||
| 75 | N-linked (GlcNAc...) asparagine |
|
||
| 172 | N-linked (GlcNAc...) asparagine |
|
||
| 204 | N-linked (GlcNAc...) asparagine |
|
||
| 237 | N-linked (GlcNAc...) asparagine |
|
||
| 248 | N-linked (GlcNAc...) asparagine |
|
||
| 281 | N-linked (GlcNAc...) asparagine |
|
||
| 307 | N-linked (GlcNAc...) asparagine |
|
||
| 492 | N-linked (GlcNAc...) asparagine |
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activation of IRF3, IRF7 mediated by TBK1, IKKε (IKBKE) | Rattus norvegicus |
| Heme signaling | Rattus norvegicus |
| IKK complex recruitment mediated by RIP1 | Rattus norvegicus |
| IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation | Rattus norvegicus |
| Ligand-dependent caspase activation | Rattus norvegicus |
| MyD88-independent TLR4 cascade | Rattus norvegicus |
| Regulation of TBK1, IKKε (IKBKE)-mediated activation of IRF3, IRF7 | Rattus norvegicus |
| Regulation of TLR by endogenous ligand | Rattus norvegicus |
| TRAF6-mediated induction of TAK1 complex within TLR4 complex | Rattus norvegicus |
| TRIF-mediated programmed cell death | Rattus norvegicus |
Disease
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050855 | renal fibrosis | |
| DOID:0060189 | ileitis | |
| DOID:11446 | sciatic neuropathy | |
| DOID:13001 | carotid stenosis | |
| DOID:3021 | acute kidney failure | |
| DOID:5082 | liver cirrhosis | |
| DOID:850 | lung disease | |
| DOID:9743 | diabetic neuropathy | |
| DOID:9970 | obesity |
