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Cathepsin Z

Summary

UniProt ID: Q9WUU7
Gene Symbol: Ctsz
Gene ID: 64138
Organism: Mus musculus (house mouse)

External Links

GlycoProtDB

GPDB0007796

GlyConnect

Cathepsin Z

GlyGen

Q9WUU7

PubChem

Q9WUU7

The O-GlcNAc Database

Q9WUU7

O-GlcNAcAtlas

Q9WUU7

Re-Glyco

Q9WUU7

Annotation

Keyword: Disulfide bond Glycoprotein Lysosome Reference proteome Signal Thiol protease Zymogen

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	Reference
proteolysis	ISO	GO_REF
proteolysis	IEA	GO_REF GO_REF
negative regulation of plasminogen activation	ISO	GO_REF
negative regulation of plasminogen activation	IEA	GO_REF
obsolete proteolysis involved in protein catabolic process

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

multicellular organismal process [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

developmental process [inference]

anatomical structure morphogenesis [inference]

morphogenesis of a branching structure [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tube morphogenesis [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a branching epithelium [inference]

branching morphogenesis of an epithelial tube [inference]

epithelial tube branching involved in lung morphogenesis

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

regulation of protein maturation [inference]

regulation of protein processing [inference]

regulation of plasminogen activation [inference]

negative regulation of plasminogen activation

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

negative regulation of plasminogen activation

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	Reference
obsolete extracellular space
lysosome	ISO	GO_REF
lysosome	IBA	GO_REF
lysosome	IEA	GO_REF GO_REF
endoplasmic reticulum	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytoplasm [inference]

cell cortex

cell surface

external encapsulating structure [inference]

extracellular matrix

site of polarized growth [inference]

growth cone

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
carboxypeptidase activity	ISO	GO_REF
carboxypeptidase activity	IEA	GO_REF
cysteine-type endopeptidase activity
cysteine-type peptidase activity	ISO	GO_REF
cysteine-type peptidase activity	IEA	GO_REF GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

cysteine-type carboxypeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

exopeptidase activity [inference]

carboxypeptidase activity

cysteine-type carboxypeptidase activity

cysteine-type exopeptidase activity [inference]

cysteine-type carboxypeptidase activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MASSGSVQQLPLVLLMLLLASAARARLYFRSGQTCYHPIRGDQLALLGRRTYPRPHEYLSPADLPKNWDWRNVNGVNYASVTRNQHIPQYCGSCWAHGSTSAMADRINIKRKGAWPSILLSVQNVIDCGNAGSCEGGNDLPVWEYAHKHGIPDETCNNYQAKDQDCDKFNQCGTCTEFKECHTIQNYTLWRVGDYGSLSGREKMMAEIYANGPISCGIMATEMMSNYTGGIYAEHQDQAVINHIISVAGWGVSNDGIEYWIVRNSWGEPWGEKGWMRIVTSTYKGGTGDSYNLAIESACTFGDPIV

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 4** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
183			G49108TO	GlyGen
186	N-linked (GlcNAc...) asparagine	30899004	G80920RR G93180LE G39188ZX G06110VR G74724QE	GlycoProtDB UniProt GlyGen GlyConnect
188		29562282 37507081	G49108TO	GlyGen The O-GlcNAc Database
226	N-linked (GlcNAc...) asparagine			UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 5** entries
Pathway Name	Organism
COPII-mediated vesicle transport	Mus musculus
Cargo concentration in the ER	Mus musculus
Lysosome Vesicle Biogenesis	Mus musculus
Metabolism of Angiotensinogen to Angiotensins	Mus musculus
Neutrophil degranulation	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

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Acknowledgements