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Transforming growth factor beta-1 proprotein

Summary

UniProt ID

P01137

Gene Symbol

TGFB1
TGFB

Organism

Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011299

GlyConnect

1835

GlyGen

P01137

PubChem

P01137

The Human Metabolome Database

HMDBP14566

RaftProt

P01137

Annotation

Keyword

3D-structure
Cleavage on pair of basic residues
Direct protein sequencing
Disease variant
Disulfide bond
Extracellular matrix
Glycoprotein
Growth factor
Mitogen
Reference proteome
Signal

Gene Ontology (GO)

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GO Term
positive regulation of inflammatory response
positive regulation of chemotaxis
ventricular cardiac muscle tissue morphogenesis
negative regulation of extracellular matrix disassembly
positive regulation of epithelial to mesenchymal transition
macrophage derived foam cell differentiation
positive regulation of fibroblast migration
negative regulation of macrophage cytokine production
oligodendrocyte development
positive regulation of microglia differentiation

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GO Term
extracellular region
extracellular space
nucleus
cytoplasm
plasma membrane
axon
extracellular matrix
collagen-containing extracellular matrix
neuronal cell body
platelet alpha granule lumen

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GO Term
enzyme binding
protein-containing complex binding
protein serine/threonine kinase activator activity
identical protein binding
cytokine activity
antigen binding
type II transforming growth factor beta receptor binding
growth factor activity
type I transforming growth factor beta receptor binding
type III transforming growth factor beta receptor binding

Annotation information from UniProt.

Sequence

MPPSGLRLLLLLLPLLWLLVLTPGRPAAGLSTCKTIDMELVKRKRIEAIRGQILSKLRLASPPSQGEVPPGPLPEAVLALYNSTRDRVAGESAEPEPEPEADYYAKEVTRVLMVETHNEIYDKFKQSTHSIYMFFNTSELREAVPEPVLLSRAELRLLRLKLKVEQHVELYQKYSNNSWRYLSNRLLAPSDSPEWLSFDVTGVVRQWLSRGGEIEGFRLSAHCSCDSRDNTLQVDINGFTTGRRGDLATIHGMNRPFLLLMATPLERAQHLQSSRHRRALDTNYCFSSTEKNCCVRQLYIDFRKDLGWKWIHEPKGYHANFCLGPCPYIWSLDTQYSKVLALYNQHNPGASAAPCCVPQALEPLPIVYYVGRKPKVEQLSNMIVRSCKCS

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 2** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
82		23586699 24498956
176		23586699

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
SMAD2/3 Phosphorylation Motif Mutants in Cancer	Homo sapiens
Syndecan interactions	Homo sapiens
TGF-beta receptor signaling activates SMADs	Homo sapiens
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)	Homo sapiens
TGFBR1 KD Mutants in Cancer	Homo sapiens
TGFBR1 LBD Mutants in Cancer	Homo sapiens
TGFBR2 Kinase Domain Mutants in Cancer	Homo sapiens
TGFBR2 MSI Frameshift Mutants in Cancer	Homo sapiens
Transcriptional regulation of white adipocyte differentiation	Homo sapiens
UCH proteinases	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

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Summary

External Links

Annotation

International Collaboration

Acknowledgements