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Tumor necrosis factor receptor superfamily member 1A

Summary

UniProt ID

P25118

Gene Symbol

Tnfrsf1a
Tnfr-1
Tnfr1

Organism

Mus musculus (house mouse)

External Links

GlycoProtDB: GPDB0003512
PubChem: P25118

Annotation

Keyword

Apoptosis
Cell membrane
Disulfide bond
Glycoprotein
Golgi apparatus
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix

Gene Ontology (GO)

Displaying entries **11 - 20** of 37 in total

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GO Term
positive regulation of neuron apoptotic process
positive regulation of lipid metabolic process
protein localization to plasma membrane
positive regulation of execution phase of apoptosis
positive regulation of apoptotic process involved in morphogenesis
regulation of membrane lipid metabolic process
negative regulation of extracellular matrix constituent secretion
transcription by RNA polymerase II
positive regulation of canonical NF-kappaB signal transduction
positive regulation of transcription by RNA polymerase II

Displaying **all 8** entries
GO Term
Golgi membrane
extracellular space
plasma membrane
axon
cell surface
protein-containing complex
receptor complex
membrane raft

Displaying **all 5** entries
GO Term
protease binding
signaling receptor activity
protein-containing complex binding
tumor necrosis factor receptor activity
tumor necrosis factor binding

Annotation information from UniProt.

Sequence

MGLPTVPGLLLSLVLLALLMGIHPSGVTGLVPSLGDREKRDSLCPQGKYVHSKNNSICCTKCHKGTYLVSDCPSPGRDTVCRECEKGTFTASQNYLRQCLSCKTCRKEMSQVEISPCQADKDTVCGCKENQFQRYLSETHFQCVDCSPCFNGTVTIPCKETQNTVCNCHAGFFLRESECVPCSHCKKNEECMKLCLPPPLANVTNPQDSGTAVLLPLVILLGLCLLSFIFISLMCRYPRWRPEVYSIICRDPVPVKEEKAGKPLTPAPSPAFSPTSGFNPTLGFSTPGFSSPVSSTPISPIFGPSNWHFMPPVSEVVPTQGADPLLYESLCSVPAPTSVQKWEDSAHPQRPDNADLAILYAVVDGVPPARWKEFMRFMGLSEHEIERLEMQNGRCLREAQYSMLEAWRRRTPRHEDTLEVVGLVLSKMNLAGCLENILEALRNPAPSSTTRLPR

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying 1 entry
Position	Description	PubMed ID	GlyTouCan ID	Source
151		23002422

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 6** entries
Pathway Name	Organism
Regulation of TNFR1 signaling	Mus musculus
TNF signaling	Mus musculus
TNFR1-induced NF-kappa-B signaling pathway	Mus musculus
TNFR1-induced proapoptotic signaling	Mus musculus
TNFR1-mediated ceramide production	Mus musculus
TNFs bind their physiological receptors	Mus musculus