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TNFR1-induced proapoptotic signaling

Summary

Organism

Mus musculus (house mouse)

Reactome

R-MMU-5357786

PubChem

R-MMU-5357786

Description

This event has been computationally inferred from an event that has been demonstrated in another species.
The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation.
More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 8** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
B2RUR8	OTU domain-containing protein 7B	Otud7b	view
P06804	Tumor necrosis factor	Tnf Tnfa Tnfsf2	view
P25118	Tumor necrosis factor receptor superfamily member 1A	Tnfr-1 Tnfr1 Tnfrsf1a	view
P35123	Ubiquitin carboxyl-terminal hydrolase 4	Unp Usp4	view
Q3U0V2	Tumor necrosis factor receptor type 1-associated DEATH domain protein	Tradd	view
Q60769	Tumor necrosis factor alpha-induced protein 3	Tnfaip3 Tnfip3	view
Q80TQ2	Ubiquitin carboxyl-terminal hydrolase CYLD	Cyld Cyld1 Kiaa0849	view
Q8K004	Spermatogenesis-associated protein 2	Spata2	view

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