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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
Disintegrin and metalloproteinase domain-containing protein 17
Summary
- UniProt ID
- P78536
- Gene Symbol
-
- ADAM17
- CSVP
- TACE
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell membrane
- Cleavage on pair of basic residues
- Direct protein sequencing
- Disulfide bond
- Glycoprotein
- Metal-binding
- Metalloprotease
- Notch signaling pathway
- Phosphoprotein
- Reference proteome
- SH3-binding
- Signal
- Transmembrane helix
- Zinc
- Zymogen
- Gene Ontology (GO)
| GO Term |
|---|
| Golgi membrane |
| cytoplasm |
| plasma membrane |
| actin cytoskeleton |
| membrane |
| apical plasma membrane |
| cytosol |
| membrane raft |
| endoplasmic reticulum lumen |
| cell surface |
| GO Term |
|---|
| peptidase activity |
| metal ion binding |
| SH3 domain binding |
| PDZ domain binding |
| endopeptidase activity |
| metalloendopeptidase activity |
| metallopeptidase activity |
| Notch binding |
| interleukin-6 receptor binding |
| integrin binding |
Sequence
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
Glycosylation Sites
| Position | Description | PubMed ID | GlyTouCan ID | Source |
|---|---|---|---|---|
| 103 |
|
|
Feature
: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt
Pathway
| Pathway Name | Organism |
|---|---|
| Activated NOTCH1 Transmits Signal to the Nucleus | Homo sapiens |
| CD163 mediating an anti-inflammatory response | Homo sapiens |
| Collagen degradation | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 PEST Domain Mutants | Homo sapiens |
| Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant | Homo sapiens |
| Growth hormone receptor signaling | Homo sapiens |
| Nuclear signaling by ERBB4 | Homo sapiens |
| Regulated proteolysis of p75NTR | Homo sapiens |
