GlyCosmos Portal

Submissions

Regulated proteolysis of p75NTR

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-193692

PubChem

R-HSA-193692

Description

p75NTR undergoes a process of regulated intramembrane proteolysis (RIP) similar to other transmembrane proteins such as NOTCH, beta-amyloid precursor protein (APP), and ERBB4. Each of these proteins is subjected to two sequential cleavages. The first one occurs in the extracellular part of the protein and is mediated by the metalloproteinase alpha-secretase which causes shedding of the extracellular domain. The second cleavage occurs in the intramembrane region and is mediated by gamma-secretase and causes release of the intracellular domain, ICD, and of a small peptide. The ICD often traffics to the nucleus and, in some instances (e.g. NOTCH), was found to act as transcriptional regulator. Whether the p75NTR ICD does translocate to the nucleus to regulate gene expression in a way similar to the NOTCH receptor remains to be seen. The alpha- and gamma-secretase mediated cleavage of p75 appears to be regulated by neurotrophin (NGF, BDNF) binding to TRKA or TRKB. p75NTR processing also occurs in response to MAG in cerebellar granule neurons.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 6** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P08138	Tumor necrosis factor receptor superfamily member 16	NGFR TNFRSF16	view
P19838	Nuclear factor NF-kappa-B p105 subunit	NFKB1	view
P78536	Disintegrin and metalloproteinase domain-containing protein 17	ADAM17 ADAM18 CSVP TACE hCG_23065	view
Q04206	Transcription factor p65	NFKB3 RELA	view
Q92542	Nicastrin	KIAA0253 NCSTN UNQ1874/PRO4317	view
Q96BI3	Gamma-secretase subunit APH-1A	APH1A CGI-78 PSF UNQ579/PRO1141	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.