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B-cell receptor CD22

Summary

GlyCosmos Lectin

GL_000078

Lectin Name Aliases

B-lymphocyte cell adhesion molecule
BL-CAM
Sialic acid-binding Ig-like lectin 2
Siglec-2
T-cell surface antigen Leu-14

Organism

Mus musculus (house mouse)

External Links

UniProt: P35329

Annotation

Keyword: Alternative splicing Cell adhesion Cell membrane Disulfide bond Glycoprotein Immunoglobulin domain Lectin Phosphoprotein Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	Reference
negative regulation of immunoglobulin production	IGI	PMID
cell adhesion
cell surface receptor signaling pathway	TAS	PMID
regulation of endocytosis	ISO	GO_REF
regulation of endocytosis	IEA	GO_REF

GO Hierarchy

biological process

immune system process [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

B cell activation

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

regulation of immune effector process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of immune response

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of localization [inference]

regulation of transport [inference]

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of immune effector process [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of immune response

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of antigen receptor-mediated signaling pathway [inference]

regulation of B cell receptor signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

regulation of intracellular signal transduction [inference]

regulation of calcium-mediated signaling [inference]

negative regulation of calcium-mediated signaling

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of production of molecular mediator of immune response [inference]

regulation of immunoglobulin production [inference]

negative regulation of immunoglobulin production

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

regulation of cell population proliferation [inference]

regulation of leukocyte proliferation [inference]

regulation of mononuclear cell proliferation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of production of molecular mediator of immune response [inference]

negative regulation of immunoglobulin production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of antigen receptor-mediated signaling pathway [inference]

negative regulation of B cell receptor signaling pathway

negative regulation of intracellular signal transduction [inference]

negative regulation of calcium-mediated signaling

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

regulation of cellular component organization [inference]

regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

regulation of lymphocyte activation [inference]

regulation of lymphocyte proliferation [inference]

regulation of B cell proliferation

regulation of B cell activation [inference]

regulation of B cell proliferation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
early endosome	ISO	GO_REF
early endosome	IBA	GO_REF
early endosome	IEA	GO_REF
plasma membrane	ISS	GO_REF
plasma membrane	ISO	GO_REF

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

cell body membrane [inference]

neuronal cell body membrane

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	Reference
coreceptor activity	TAS	PMID
protein phosphatase binding	IBA	GO_REF
protein phosphatase binding	IPI	PMID
carbohydrate binding
sialic acid binding	IBA	GO_REF

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

CD4 receptor binding

enzyme binding [inference]

phosphatase binding [inference]

protein phosphatase binding

carbohydrate binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

sialic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

sialic acid binding

carbohydrate derivative binding [inference]

sialic acid binding

molecular transducer activity [inference]

signaling receptor activity [inference]

coreceptor activity

Gene Ontology information from UniProt.

Annotation information from UniProt.

Pathway

Displaying **all 3** entries
Pathway Name	Organism
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Mus musculus
CD22 mediated BCR regulation	Mus musculus
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Mus musculus

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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