Pathogen Adherence to Carbohydrate Database (PACDB)

PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.

Source Last Updated
Pathogen Adherence to Carbohydrate Database (PACDB) June 1, 2016
Displaying entries 1 - 25 of 1840 in total
Species Pathogen Adherence Molecule Ligand Name Ligand Feature Target Source Glycan Sequence Binding PubMed ID
Clostridium botulinum Botulinum neurotoxin (type C) GD1b Disialoglycosphingolipids Presynaptic neuronal cells Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 18242046
Clostridium tetani Tetanus toxin GD1b Disialoglycosphingolipids Brain membrane Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 6257717
Clostridium botulinum BoNT/C (located within amino acid residues 1122-1290) GD1b Disialoglycosphingolipids Presynaptic neuronal cells Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 18242046
Influenza virus Hemagglutinin (HA) GD1a Disialoglycosphingolipids Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 11030743
Actinomyces naeslundii Unknown GD1b Disialoglycosphingolipids Human brain Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 2358461
Clostridium tetani Unknown GD1b Disialoglycosphingolipids Brain membrane Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 6257717
Escherichia coli S-fimbriae (SfaA) Seminolipid (Sulfogalactosylglycerolipid) Glycolipids Brain endothelial cells Gal(3SO4)(b1-1)-alkylacylglycerol Binding 8098039
Escherichia coli S-fimbriae Sialyl galactoside units of cell surface glycoproteins Glycoproteins Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles NeuAc(a2-3)Gal(b1-4)Glc Binding 2893810
Norovirus Unknown Sialylated type 2 chain conjugates (S-type 2-HSA) Glycoproteins Human serum albumin NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD Binding 19054801
Norovirus Unknown Sialyl Lewis x (SLex-HSA) Glycoproteins Human serum albumin NeuAc(a2-3)Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(c)-APD Binding 19054801
Helicobacter pylori Fibrillar hemmagglutinin N-acetylneuraminyl-a(2-3)-galactopyranosyl sequence Glycoproteins Gastric epithelium, Mucus layer of the stomach NeuAc(a2-3)Gal Binding 2459065
Polyoma virus SV40 GM1 Monosialoglycosphingolipids (broad range) Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 18809496
Helicobacter pylori Adhesins Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) Monosialoglycosphingolipids Human leukocytes, Human neutrophils NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer Binding 10569742
Escherichia coli K99 GM3(NeuGc) Monosialoglycosphingolipids Pig small intestine NeuGc(a2-3)Gal(b1-4)Glc(b1-1)Cer Binding 7849044
Escherichia coli CS3 (coli surface 3)-fimbriae GM1 Monosialoglycosphingolipids Intestinal epithelium, Rabbit intestine Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 7822033
Escherichia coli CS3 (coli surface 3)-fimbriae GM2(NeuAc) Monosialoglycosphingolipids Intestinal epithelium, Rabbit intestine GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 7822033
Moraxella catarrhalis Fimbriae GM2(NeuAc) Monosialoglycosphingolipids Human pharyngeal epithelial cells GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 12137200
Influenza virus Unknown GM3(NeuAc) Monosialoglycosphingolipids Granulocytes NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer Binding 8823909
Influenza virus Unknown Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) Monosialoglycosphingolipids Granulocytes NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer Binding 8823909
Helicobacter pylori Adhesins GM3(NeuAc) Monosialoglycosphingolipids Human gastric mucosa NeuAc(a2-3)Gal(b1-4)Glc(b1-1)Cer Binding 2037054
Streptococcus pneumoniae CTB-PsaA pentamers GM1 Monosialoglycosphingolipids Serum, Saliva, Nasal/bronchial wash samples Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 15358234
Sendai virus Unknown Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) Monosialoglycosphingolipids Granulocytes NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer Binding 8823909
Influenza virus Hemagglutinin (HA) Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) Monosialoglycosphingolipids Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer Binding 11030743
Actinomyces naeslundii Unknown GM1 Monosialoglycosphingolipids Human brain Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer Binding 2358461
Escherichia coli S-fimbriae unnamed ligand Oligosaccharides Neural cell lines NeuAc(a2-3)Gal(b1-3)GalNAc Binding 16564136

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