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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name ▲ | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Vibrio cholerae | Cholera toxin | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Escherichia coli | F1C | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 10816509 | |
| Escherichia coli | Unknown | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Clostridium tetani | Tetanus toxin | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Clostridium tetani | Unknown | DSPG (Disialosyl paragloboside) | Disialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 7527546 | |
| Foot-and-mouth disease virus | Natural ligand of integrin [alpha]v[beta]3 | De-N-sulfated heparin | Glycosaminoglycans | Extracellular matrix (ECM) | Not Binding | 8764038 | |
| Borrelia burgdorferi | DbpA | Decorin | Proteoglycans | Extracellular matrix (ECM) | Binding | 12761224 | |
| Borrelia burgdorferi | "DbpA, DbpB, Bgp" | Decorin | Proteoglycans | Binding | 16299269 | ||
| Borrelia afzelii | Unknown | Dermatan sulfate | Glycosaminoglycans | Glial cells | Binding | 10085013 | |
| Borrelia burgdorferi | BBK32 | Dermatan sulfate | Glycosaminoglycans | Mammalian cell surface | Binding | 16368999 | |
| Borrelia burgdorferi | Unknown | Dermatan sulfate | Glycosaminoglycans | Glial cells | Binding | 10085013 | |
| Borrelia burgdorferi | "DbpA, DbpB, Bgp" | Dermatan sulfate | Glycosaminoglycans | Binding | 16299269 | ||
| Borrelia burgdorferi | Unknown | Dermatan sulfate | Glycosaminoglycans | Vero cells | Not Binding | 9826395 | |
| Bordetella pertussis | FHA (442-863) | Dextran sulfate | Polysaccharides | WiDr cells, HeLa cells, Vero cells, Extracellular matrix (ECM) | Binding | 11348687 | |
| Human immunodeficiency virus | Unknown | Dextran sulfate | Polysaccharides | Human T cells | Binding | 9420059 | |
| Chlamydia trachomatis | Unknown | Dextran sulfate | Polysaccharides | HeLa cells | Binding | 9420059 | |
| Herpes simplex virus | Unknown | Dextran sulfate | Polysaccharides | Human cervical cells | Binding | 9420059 | |
| Neisseria gonorrhoeae | Unknown | Dextran sulfate | Polysaccharides | Human epithelial cells | Binding | 9420059 | |
| Foot-and-mouth disease virus | Natural ligand of integrin [alpha]v[beta]3 | Dextran sulfate | Polysaccharides | Extracellular matrix (ECM) | Not Binding | 8764038 | |
| Escherichia coli | F1C | Disialosyl lacto-N-nor-hexaosylceramide (DSnHC) | Sialoglycosphingolipids | NeuAc(a2-8)NeuAc(a2-3)[Gal(b1-4)GlcNAc]2(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 10816509 | |
| Influenza virus | Unknown | Endothelial cell-specific molecule (ESM) | Proteoglycans | Not Binding | 1740131 | ||
| Helicobacter pylori | Unknown | Epithelial type of glycolipid containing 2-hydroxy fatty acid | Glycolipids | Binding | 8574698 | ||
| Vibrio cholerae | Cholera toxin | Extended GM1 | Monosialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7527546 | |
| Vibrio cholerae | Unknown | Extended GM1 | Monosialoglycosphingolipids | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7527546 | |
| Helicobacter pylori | Adhesins | Fetuin | Glycoproteins | Human leukocytes, Human neutrophils | Binding | 10569742 |
