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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source ▲ | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Campylobacter upsaliensis | Unknown | Mucin | Glycoproteins | Human small intestine | Binding | 8926069 | |
| Lactobacillus johnsonii | Unknown | Lewis a (Lea) (GSL) | Glycosphingolipids | Human small intestine | Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 11087711 |
| Escherichia coli | F1C | H5 type 1 pentaglycosylceramide (lacto-series) | Oligoglycosylceramides | Human small intestine | Fuc(a1-2)Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 11877427 |
| Helicobacter pylori | Unknown | Salivary glycoprotein (gp340) | Glycoproteins | Human stomach associated with gastritis and peptic ulcer disease | Binding | 11007786 | |
| Shigella dysenteriae | B subunit | Gal-nLc4Cer; P1 antigen (GSL) | Oligoglycosylceramides | Human type B erythrocytes | Gal(a1-4)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 3519828 |
| Paracoccidioides brasiliensis | Adhesins | Fibronectin | Glycoproteins | Human type II alveolar cells (A549) | Binding | 18083324 | |
| Paracoccidioides brasiliensis | Adhesins | Fibrinogen | Glycoproteins | Human type II alveolar cells (A549) | Binding | 18083324 | |
| Escherichia coli | K99 | unnamed ligand | Oligosaccharides | Intestinal cells | NeuAc(a2-3)Gal(b1-4)Glc | Binding | 16564136 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Salmonella typhimurium | Unknown | Mannose | Monosaccharides | Intestinal cells | Man | Binding | 16564136 |
| Campylobacter jejuni | Unknown | unnamed ligand | Oligosaccharides | Intestinal cells | Fuc(a1-2)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Escherichia coli | K99 | Mucin | Glycoproteins | Intestinal cells | Binding | 7849044 | |
| Escherichia coli | CFA/1 | Sialic acid (α2,8) | Saccharides | Intestinal cells | NeuAc(a2-8) | Binding | 16564136 |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Entamoeba histolytica | Raft-like plasma membrane domains | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Lactose | Disaccharides | Intestinal epithelial cells (T84) | Gal(b1-4)Glc | Binding | 17156748 |
| Clostridium botulinum | HA | Lactose | Disaccharides | Intestinal epithelial cells (T84) | Gal(b1-4)Glc | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | HA | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylglucosamine | Monosaccharides | Intestinal epithelial cells (T84) | GlcNAc | Not Binding | 17156748 |
