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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature ▲ | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Rotavirus | VP8 | Sialic acid | Monosaccharides | Epithelial cells of small intestine | Binding | 16511112 | |
| Influenza virus | Unknown | Neuraminic acid | Monosaccharides | Binding | 8574698 | ||
| Helicobacter pylori | Unknown | Sialic acid | Monosaccharides | Binding | 8574698 | ||
| Newcastle disease virus | HN(hemagglutinin-neuraminidase) glycoproteins | Sialic acid | Monosaccharides | Binding | 17205603 | ||
| Sendai virus | "HN (hemagglutinin neuraminidase), F (fusion protein)" | Sialic acid | Monosaccharides | Binding | 8574698 | ||
| Rotavirus | VP8 (galectin) | Sialic acid(2-O-methyl-α-Neu5Ac (Neu5Ac2Me)) | Monosaccharides | Binding | 17306299 | ||
| Rotavirus | VP8 (spike protein) | Sialic acid | Monosaccharides | Binding | 17277447 | ||
| Rotavirus | VP8 | Sialic acid | Monosaccharides | Binding | 18540062 | ||
| Helicobacter pylori | Unknown | Sialic acid | Monosaccharides | Binding | 16088272 | ||
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylglucosamine | Monosaccharides | Intestinal epithelial cells (T84) | GlcNAc | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Mannose | Monosaccharides | Intestinal epithelial cells (T84) | Man | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Clostridium botulinum | HA | N-Acetylglucosamine | Monosaccharides | Intestinal epithelial cells (T84) | GlcNAc | Not Binding | 17156748 |
| Clostridium botulinum | HA | Mannose | Monosaccharides | Intestinal epithelial cells (T84) | Man | Not Binding | 17156748 |
| Clostridium botulinum | HA | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Pseudomonas aeruginosa | PA-IIL | L-Galactose | Monosaccharides | Gal | Binding | 10967261 | |
| Escherichia coli | NeuC protein of K1 capsule (UDP GlcNAc 2-epimerase)) | N-Acetylglucosamine | Monosaccharides | GlcNAc | Not Binding | 14729696 | |
| Pseudomonas aeruginosa | LecB | alpha-methyl-fucoside | Monosaccharides | A549 cells | Binding | 19237519 | |
| Pseudomonas aeruginosa | LecA | Alpha-methyl-galactoside | Monosaccharides | A549 cells | Binding | 19237519 | |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Fucose | Monosaccharides | Intestinal epithelial cells (T84) | Fuc | Not Binding | 17156748 |
| Clostridium botulinum | HA | Fucose | Monosaccharides | Intestinal epithelial cells (T84) | Fuc | Not Binding | 17156748 |
| Polyoma virus | SV40 | GM1 | Monosialoglycosphingolipids | (broad range) | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18809496 |
| Helicobacter pylori | Adhesins | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | Human leukocytes, Human neutrophils | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 10569742 |
| Escherichia coli | K99 | GM3(NeuGc) | Monosialoglycosphingolipids | Pig small intestine | NeuGc(a2-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 7849044 |
| Escherichia coli | CS3 (coli surface 3)-fimbriae | GM1 | Monosialoglycosphingolipids | Intestinal epithelium, Rabbit intestine | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7822033 |
