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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source ▲ | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Streptococcus pneumoniae | Adhesins | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Type-II lung cells, Vascular endothelial cells | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7752878 |
| Shigella dysenteriae | Stx | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Ubiquitously expressed in most tissues (e.g. human erythrocytes/endothelium/kidney/platelet) | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9712788 |
| Escherichia coli | F1C | unnamed ligand | Saccharides | Urine | GalNAc(b1-4)Gal(b | Binding | 16564136 |
| Escherichia coli | P-fimbriae | Gb2 (Galabiosylceramide) | Diosylceramides | Urine | Gal(a1-4)Gal(b1-1)Cer | Binding | 16564136 |
| Escherichia coli | Type 1-fimbriae | unnamed ligand | Oligosaccharides | Urine | Man(a1-3)Man(a1-6)Man | Binding | 16564136 |
| Escherichia coli | F17 | N-Acetylglucosamine | Monosaccharides | Urine (microvilli of the intestinal epithelium of ruminants) | GlcNAc | Binding | 16564136 |
| Escherichia coli | PapG | alpha-D-galactopyranosyl-(1-4)-beta-D-galactopyranose | Disaccharides | Uroepithelial cells | Gal(a1-4)Gal | Binding | 2886993 |
| Escherichia coli | P-pili | Globo-series GSL | Glycosphingolipids | Uroepithelial cells, Erythrocytes | Gal(a1-4)Gal | Binding | 9973330 |
| Escherichia coli | PapG | Globo-series GSL | Glycosphingolipids | Uroepithelial cells, Erythrocytes | Gal(a1-4)Gal | Binding | 9973330 |
| Listeria monocytogenes | Unknown | α-GalCer/CD1d tetramers | Glycoconjugates | V[alpha]14+ NK1.1- T cells in infected liver of mice | Binding | 16988270 | |
| Influenza virus | Hemagglutinin (HA) | GD1a | Disialoglycosphingolipids | Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 11030743 |
| Influenza virus | Hemagglutinin (HA) | Sialyl-3-Paragloboside (S-3-PG; α2,3-sialylparagloboside) | Monosialoglycosphingolipids | Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 11030743 |
| Influenza virus | Hemagglutinin (HA) | GT1b | Trisialoglycosphingolipids | Various human tissues (leukocytes/erythrocytes/small intestine/stomach/meconium/colon/pancreas) | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 11030743 |
| Actinomyces naeslundii | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | Gal(a1-3)[Fuc(a1-2)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces viscosus | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces naeslundii | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces viscosus | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | Gal(a1-3)[Fuc(a1-2)]Gal(b1-4)[Fuc(a1-3)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | Glucosylceramide | Monoglycosylceramides | Various sources | Glc(b1-1)Cer | Not Binding | 9499377 |
| Actinomyces viscosus | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | Gal(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces viscosus | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces naeslundii | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | Gal(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Actinomyces naeslundii | Unknown | unnamed ligand | Oligoglycosylceramides | Various sources | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2358461 |
| Streptococcus pneumoniae | Adhesins | D-Galactose | Monosaccharides | Vascular endothelial cells (only) | Gal | Binding | 7752878 |
| Escherichia coli | S-fimbriae | Sialyl galactoside units of cell surface glycoproteins | Glycoproteins | Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles | NeuAc(a2-3)Gal(b1-4)Glc | Binding | 2893810 |
| Hantaan virus | SBA (soybean agglutinin) | N-Acetylgalactosamine | Monosaccharides | Vero E6/P388D1 cells | GalNAc | Binding | 10542025 |
