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MIRAGE
Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▲ | PubMed ID |
|---|---|---|---|---|---|---|---|
| Neisseria meningitidis | Unknown | Pentasaccharide | Oligosaccharides | Respiratory tract | NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 16564136 |
| Reovirus | Unknown | Sialic acid (α2,3) | Saccharides | Most organs including the central nervous system/heart/liver | NeuAc(a2-3) | Binding | 18216114 |
| Escherichia coli | CFA/1 | Sialic acid (α2,8) | Saccharides | Intestinal cells | NeuAc(a2-8) | Binding | 16564136 |
| Theiler's murine encephalomyelitis virus | VP2 amino acids on puff B | Sialic acid (α2,3) | Saccharides | Central nervous system | NeuAc(a2-3) | Binding | 16575521 |
| Lactobacillus johnsonii | Unknown | NeuGc3-nLc6Cer | Sialoglycosphingolipids | Rabbit thymus | NeuGc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 11087711 |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | NeuGc3-nLc6Cer | Sialoglycosphingolipids | Rabbit thymus | NeuGc(a2-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 9228091 |
| Escherichia coli | S-fimbriae (SfaA) | Galactosyl sulfatide | Sulfoglycosphingolipids | Brain endothelial cells | Gal(3SO4)(b1-1)Cer | Binding | 8098039 |
| Mycoplasma pneumoniae | Unknown | Galactosylceramide 6-sulfate | Sulfoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | Gal(6SO4)(b1-1)Cer | Binding | 2470753 |
| Mycoplasma pneumoniae | Unknown | Galactosyl sulfatide | Sulfoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | Gal(3SO4)(b1-1)Cer | Binding | 2470753 |
| Mycoplasma pneumoniae | Unknown | Sulfated glucuronyl paragloboside | Sulfoglycosphingolipids | Human colon adenocarcinoma cells (WiDr ) | GlcA(3SO4)(b1-3)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2470753 |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | Sulfo-gangliotetraosylceramide (Sulfo-GgO4) | Sulfoglycosphingolipids | Mouse intestine | HSO3(-3)Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9228091 |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Foot-and-mouth disease virus | VP1 (RGD peptide) | Heparan sulfate (independent of expression of αvβ3 Integrin on cell-sulface) | Glycosaminoglycans | Extracellular matrix (ECM) | Binding | 9557639 | |
| Streptococcus pneumoniae | CBPs (choline-binding proteins) | Sialic acid | Monosaccharides | Cytokine-activated cells | Binding | 12640357 | |
| Helicobacter pylori | SabA (sialic acid-binding adhesin) | Sialic acid | Monosaccharides | Human neutrophils | Binding | 15689619 | |
| Rabies virus | Unknown | Sialic acid | Monosaccharides | Chicken embryo related cells | Binding | 3583664 | |
| Parvovirus | Unknown | Sialic acid (both O- and N-linked) | Monosaccharides | Nucleated bovine cells | Binding | 15269359 | |
| Escherichia coli | SfaI-S | Sialic acid | Monosaccharides | Epithelial cells, Extracellular matrix (ECM) | Binding | 10732678 | |
| Streptococcus gordonii | Adhesins | Sialic acid | Monosaccharides | HL-60 promyelocytic leukemia cell line, Leukosialin (CD43) | Binding | 11035744 | |
| Streptococcus gordonii | Hsa | Sialic acid | Monosaccharides | Human oral cavity (erythrocytes and polymorphonuclear leukocytes) | Binding | 16177339 | |
| Streptococcus pneumoniae | CbpA; SpsA; PbcA; PspC (CBPs) | Sialic acid | Monosaccharides | Cytokine activated epithelial and endothelial cells | Binding | 10341176 | |
| Reovirus | sigma 1 proteins | Sialic acid | Monosaccharides | Murine intestine, Murine spleen, Murine liver, Murine brain, Human cholangiocarcinoma cells | Binding | 12813018 | |
| Bordetella pertussis | Iron-induced surface-exposed proteins | Sialic acid | Monosaccharides | Respiratory epithelial cells (A549) | Binding | 17727651 |
