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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source ▼ | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | S-fimbriae (SfaA) | Galactosylceramide (Galactocerebroside) | Monoglycosylceramides | Brain endothelial cells | Gal(b1-1)Cer | Binding | 8098039 |
| Escherichia coli | S-fimbriae (SfaA) | Galactosyl sulfatide | Sulfoglycosphingolipids | Brain endothelial cells | Gal(3SO4)(b1-1)Cer | Binding | 8098039 |
| Escherichia coli | S-fimbriae (SfaA) | Lactosylceramide (Lactocerebroside) | Diosylceramides | Brain endothelial cells | Gal(b1-4)Glc(b1-1)Cer | Binding | 8098039 |
| Mycoplasma pneumoniae | Adhesins | Fetuin | Glycoproteins | Bovine erythrocytes | Binding | 2470754 | |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | I-active Sialyl lactoisooctaosylceramide | Sialoglycosphingolipids | Bovine erythrocytes | Gal(a1-3)Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-3)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9228091 |
| Lactobacillus johnsonii | Unknown | unnamed ligand | Sialoglycosphingolipids | Bovine buttermilk | Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 11087711 |
| Helicobacter pylori | Neutrophil-activating proteins (150-kDa) | unnamed ligand | Sialoglycosphingolipids | Bovine buttermilk | Gal(b1-4)GlcNAc(b1-6)[NeuAc(a2-6)Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9228091 |
| Lactobacillus johnsonii | Unknown | unnamed ligand | Oligoglycosylceramides | Bovine buttermilk | Gal(b1-4)GlcNAc(b1-6)[Gal(b1-4)GlcNAc(b1-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 11087711 |
| Influenza virus | Unknown | Gangliosides | Sialoglycosphingolipids | Bovine brain | Binding | 1740131 | |
| Neisseria meningitidis | Type 4-pili | Thyroglobulin containing N-linked complex and hybrid (oligomannosidic) glycans | Glycoproteins | Bovine | Binding | 16177210 | |
| Bordetella pertussis | Pertussis toxin | Fetuin | Glycoproteins | Bovine | Binding | 14532091 | |
| Bordetella pertussis | Unknown | Fetuin | Glycoproteins | Bovine | Binding | 14532091 | |
| Escherichia coli | Type 1-pili | D-Mannose | Monosaccharides | Bladder epithelium | Man | Binding | 12010488 |
| Escherichia coli | FimCH-chaperone-adhesin complex | D-Mannose | Monosaccharides | Bladder epithelium | Man | Binding | 12010488 |
| Foot-and-mouth disease virus | VP1 protein (RGD motif) | αvβ3 Integrin | Glycoproteins | BHK-21/LLC-MK2/HeLa/BK-LF | Binding | 7533862 | |
| Coronavirus | Unknown | MHVR (murine member of the carcinoembryonic antigen family of glycoproteins) | Glycoproteins | BHK-21 cells | Binding | 1318394 | |
| Influenza virus | Residues 226 (glutamine) and 228 (glycine) | Sialic acid linked to α2,3Galβ1,3GalNAc | Oligosaccharides | Avian/equine isolates | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 7975212 |
| Staphylococcus aureus | Unknown | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Apical membrane of cystic fibrosis epithelia, Patients with pneumonia | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7708767 |
| Pseudomonas aeruginosa | Unknown | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Apical membrane of cystic fibrosis epithelia | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7708767 |
| Influenza virus | Hemagglutinin | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Influenza virus | Hemagglutinin H1(1934) | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Paramyxovirus | Hemagglutinin H1(1934) | Human and avian receptors containing sialylated glycoconjugates | Glycoconjugates | Airways | Binding | 18809496 | |
| Pseudomonas aeruginosa | PA-IIL | Lewis a (Lea) (GSL) | Glycosphingolipids | Airways | Gal(b1-3)[Fuc(a1-4)]GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 18809496 |
| Escherichia coli | PrsG (class III) G adhesins | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | Acute cystitis patients | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | |
| Escherichia coli | P-fimbriae | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | Acute cystitis patients | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding |
