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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▲ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Yersinia pestis | PsaA/B (pH-6 antigen) | GT1b | Trisialoglycosphingolipids | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9712817 | |
| Escherichia coli | PsaA/B (pH-6 antigen) | Glucosylceramide | Monoglycosylceramides | Glc(b1-1)Cer | Not Binding | 9712817 | |
| Yersinia pestis | PsaA/B (pH-6 antigen) | Glucosylceramide | Monoglycosylceramides | Glc(b1-1)Cer | Not Binding | 9712817 | |
| Escherichia coli | PsaA/B (pH-6 antigen) | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9712817 | |
| Escherichia coli | PsaA/B (pH-6 antigen) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9712817 | |
| Yersinia pestis | PsaA/B (pH-6 antigen) | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9712817 | |
| Yersinia pestis | PsaA/B (pH-6 antigen) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9712817 | |
| Streptococcus pneumoniae | PspC (Lary family) (alias: SpsA/CbpA/PbcA/Hic) | C3 and complement factor H | Glycoproteins | Binding | 12640357 | ||
| Streptococcus pneumoniae | PspC (Lary family) (alias: SpsA/CbpA/PbcA/Hic) | IgA | Glycoproteins | Binding | 12640357 | ||
| Escherichia coli | Pyelonephritic adhesins | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | Kidney | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 18809496 |
| Foot-and-mouth disease virus | RGD motif of the VP1 GH loop | αvβ6 Integrin | Glycoproteins | Epithelial cells | Binding | 10799568 | |
| Ralstonia solanacearum | RS-IIL (homologous to PA-IIL) | Mannose | Monosaccharides | Man | Binding | 16762477 | |
| Ralstonia solanacearum | RS-IIL (homologous to PA-IIL) | Fucose | Monosaccharides | Fuc | Binding | 16762477 | |
| Ralstonia solanacearum | RSL (30-kDa proteins) | Blood group H antigen | Disaccharides | Fuc(a1-2)Gal | Binding | 16762477 | |
| Ralstonia solanacearum | RSL (30-kDa proteins) | Blood group B antigen | Oligosaccharides | Gal(a1-3)[Fuc(a1-2)]Gal | Binding | 16762477 | |
| Ralstonia solanacearum | RSL (30-kDa proteins) | Blood group A antigen | Oligosaccharides | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)GlcNAc | Binding | 16762477 | |
| Entamoeba histolytica | Raft-like plasma membrane domains | N-Acetylgalactosamine | Monosaccharides | Intestinal cells | GalNAc | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | Galactose | Monosaccharides | Intestinal cells | Gal | Binding | 15322032 |
| Entamoeba histolytica | Raft-like plasma membrane domains | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Influenza virus | Residues 226 (glutamine) and 228 (glycine) | Sialic acid linked to α2,3Galβ1,3GalNAc | Oligosaccharides | Avian/equine isolates | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 7975212 |
| Influenza virus | Residues 226 (leucine) and 228 (serine) | Sialic acid α2,6Galβ1,4GalNAc | Oligosaccharides | Human isolates | NeuAc(a2-6)Gal(b1-4)GalNAc | Binding | 7975212 |
| Escherichia coli | S-fimbriae | Sialyl galactoside units of cell surface glycoproteins | Glycoproteins | Vascular endothelial/epithelial cells of the choroid plexus, Ependyma cells lining the brain ventricles | NeuAc(a2-3)Gal(b1-4)Glc | Binding | 2893810 |
| Escherichia coli | S-fimbriae | unnamed ligand | Oligosaccharides | Neural cell lines | NeuAc(a2-3)Gal(b1-3)GalNAc | Binding | 16564136 |
| Escherichia coli | S-fimbriae | alpha-sialyl-beta-2,3-galactose-containing glycolipids and glycoproteins | Glycoconjugates | NeuAc(a2-3)Gal(b | Binding | 2883653 | |
| Escherichia coli | S-fimbriae | unnamed ligand | Glycoconjugates | NeuAc(a2-3)Gal(b | Binding | 11454740 |
