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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▲ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | Shiga toxin (Stx1/Stx2/Stx2c/Stx2d) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 11179385 | |
| Escherichia coli | Shiga toxin (Stx2) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Vero cells | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 15292153 |
| Escherichia coli | Shiga toxin (Stx2e) | Gb4 (Globoside; Globotetraose; P antigen) | Oligoglycosylceramides | GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 11179385 | |
| Escherichia coli | Shiga-like toxin (Stx1) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | GI/kidney | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 18809496 |
| Escherichia coli | Shiga-like toxin (Stx1) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 3284526 | |
| Escherichia coli | Shiga-like toxin (Stx1) | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 18541402 | |
| Streptococcus sobrinus | SpaA (Antigen I/II Family) | Salivary glycoprotein | Glycoproteins | Tooth surface | Binding | 10341176 | |
| Streptococcus mutans | SpaP (Antigen I/II Family) | Salivary glycoprotein | Glycoproteins | Saliva | Binding | 12640357 | |
| Streptococcus mutans | SpaP (Antigen I/II Family) | Salivary glycoprotein | Glycoproteins | Tooth surface | Binding | 10341176 | |
| Streptococcus sobrinus | SpaP (Antigen I/II Family) | Salivary glycoprotein | Glycoproteins | Saliva | Binding | 12640357 | |
| Streptococcus pneumoniae | SpsA | IgA | Glycoproteins | Binding | 10341176 | ||
| Streptococcus sanguis | SsaB (Lary family) | Salivary glycoprotein | Glycoproteins | Saliva | Binding | 12640357 | |
| Streptococcus sanguis | SsaB (Lral family) | Salivary glycoprotein | Glycoproteins | Tooth surface | Binding | 10341176 | |
| Streptococcus gordonii | SspA (Antigen I/II) | Salivary glycoprotein | Glycoproteins | Saliva | Binding | 12640357 | |
| Streptococcus gordonii | SspA (Antigen I/II) | Salivary glycoprotein | Glycoproteins | Tooth surface | Binding | 10341176 | |
| Streptococcus gordonii | SspA/SspB (AgI/II family) | Collagen (type I) | Glycoproteins | humHn oral cavity (root dentine) | Binding | 16177339 | |
| Streptococcus gordonii | SspA/SspB (AgI/II family) | Salivary glycoprotein (gp340) | Glycoproteins | Human oral cavity (in fluid and surface-associated phases) | Binding | 16177339 | |
| Streptococcus gordonii | SspA/SspB (AgI/II family) | unknown carbohydrate ligand | Saccharides | Platelet | Binding | 16177339 | |
| Streptococcus gordonii | SspB (Antigen I/II) | Salivary glycoprotein | Glycoproteins | Saliva | Binding | 12640357 | |
| Streptococcus gordonii | SspB (Antigen I/II) | Salivary glycoprotein | Glycoproteins | Tooth surface | Binding | 10341176 | |
| Shigella dysenteriae | Stx | Platelet-specific GSL (Stx band 0.03) | Glycosphingolipids | Human platelets | Binding | 9712788 | |
| Shigella dysenteriae | Stx | Gb3 (Globotriaosylceramide; Trihexosylceramide; Pk antigen (GSL); CTH) | Oligoglycosylceramides | Ubiquitously expressed in most tissues (e.g. human erythrocytes/endothelium/kidney/platelet) | Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 9712788 |
| Rotavirus | TLP (Triple-layered virus particles) | Gangliosides | Sialoglycosphingolipids | Binding | 10659372 | ||
| Clostridium tetani | TeNT | Polysialogangliosides and other acidic lipids | Glycolipids | Presynaptic membrane of neuromuscular junction | Binding | 7527117 | |
| Clostridium tetani | Tetanus neurotoxin | GM2(NeuAc) | Monosialoglycosphingolipids | GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15973004 |
