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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name ▲ | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | F1C | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 10816509 | |
| Shigella dysenteriae | Unknown | Gb5 (Forssman glycolipid) | Oligoglycosylceramides | GalNAc(a1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 2435422 | |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | GgO3 (de-N- acylated) | Oligoglycosylceramides | Guinea pig erythrocytes | GalNH2(b1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9499377 |
| Helicobacter pylori | 35S-labeled or 125I-labeled proteins | GgO4 (de-N-acylated) | Oligoglycosylceramides | Mouse small intestine | Gal(b1-3)GalNH2(b1-4)Gal(b1-4)Glc(b1-1)Cer | Not Binding | 9499377 |
| Escherichia coli | K88ab | GlcNAc residues in the core of N-glycan on pSTf (porcine serum transferrin) | N-glycans | Porcine serum | Binding | 11953368 | |
| Escherichia coli | 20K-fimbriae | GlcNAc sequence | Saccharides | Human colon carcinoma Caco-2 cell line | GlcNAc | Binding | 8557360 |
| Streptococcus pneumoniae | Adhesins | GlcNAc(b1-3)Gal sequence | Saccharides | Human endothelial cells | GlcNAc(b1-3)Gal | Binding | 6886624 |
| Escherichia coli | NeuC protein of K1 capsule (UDP GlcNAc 2-epimerase)) | GlcNAc-6-P | Saccharides | Not Binding | 14729696 | ||
| Escherichia coli | (class I/II/III) | Globo-A | Oligoglycosylceramides | Binding | 7721812 | ||
| Escherichia coli | P-fimbriae | Globo-A | Oligoglycosylceramides | Binding | 7721812 | ||
| Escherichia coli | P-pili | Globo-series GSL | Glycosphingolipids | Uroepithelial cells, Erythrocytes | Gal(a1-4)Gal | Binding | 9973330 |
| Escherichia coli | PapG | Globo-series GSL | Glycosphingolipids | Uroepithelial cells, Erythrocytes | Gal(a1-4)Gal | Binding | 9973330 |
| Neisseria gonorrhoeae | N-methylphenyl-alanine pili | Glucosamine-galactose carbohydrate | Disaccharides | Binding | 12640357 | ||
| Vibrio cholerae | MSHA (mannose/glucose-specific hemagglutinin) | Glucose | Monosaccharides | Patient with acute watery diarrhea | Glc | Binding | 10219594 |
| Treponema pallidum | Tp38 (TpMglB-2) lipoproteins | Glucose | Monosaccharides | Glc | Binding | 15060032 | |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Clostridium botulinum | HA | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Bordetella pertussis | PT (subunits S2/S3 of B oligomer) | Glucosylceramide | Monoglycosylceramides | Human cilia of the respiratory epithelium | Glc(b1-1)Cer | Binding | 1729677 |
| Bordetella pertussis | Pertussis toxin | Glucosylceramide | Monoglycosylceramides | Human cilia of the respiratory epithelium | Glc(b1-1)Cer | Binding | 1729677 |
| Mycoplasma pneumoniae | Unknown | Glucosylceramide | Monoglycosylceramides | Human colon adenocarcinoma cells (WiDr ) | Glc(b1-1)Cer | Binding | 2470753 |
| Lactobacillus casei | Unknown | Glucosylceramide | Monoglycosylceramides | Intestinal tract | Glc(b1-1)Cer | Binding | 8912650 |
| Escherichia coli | F1C | Glucosylceramide | Monoglycosylceramides | Glc(b1-1)Cer | Binding | 10816509 | |
| Actinobacillus pleuropneumoniae | LPS | Glucosylceramide | Monoglycosylceramides | Glc(b1-1)Cer | Binding | 10496867 | |
| Escherichia coli | PrsG (class III) | Glucosylceramide | Monoglycosylceramides | Colonic adenocarcinoma | Glc(b1-1)Cer | Not Binding | 9673272 |
| Escherichia coli | PapG (class I) | Glucosylceramide | Monoglycosylceramides | Colonic adenocarcinoma | Glc(b1-1)Cer | Not Binding | 9673272 |
