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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding ▼ | PubMed ID |
|---|---|---|---|---|---|---|---|
| Escherichia coli | F1C | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Human meconium | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 11877427 |
| Propionibacterium granulosum | Lectin-like proteins (adhesin) | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Human skin | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2468365 |
| Actinomyces viscosus | Unknown | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Human meconium | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Lactobacillus johnsonii | Unknown | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Human meconium | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 11087711 |
| Shigella dysenteriae | B subunit | Gal-nLc4Cer; P1 antigen (GSL) | Oligoglycosylceramides | Human type B erythrocytes | Gal(a1-4)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 3519828 |
| Shigella dysenteriae | B subunit | Gal-Gb3 | Oligoglycosylceramides | Rat small intestine | Gal(a1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 3543013 |
| Shigella dysenteriae | B subunit | Gal-nLc4Cer; P1 antigen (GSL) | Oligoglycosylceramides | Human erythrocytes | Gal(a1-4)Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 3543013 |
| Actinomyces naeslundii | Unknown | Lc4Cer (Lactotetraosylceramide) | Oligoglycosylceramides | Human meconium | Gal(b1-3)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Actinomyces naeslundii | Unknown | unnamed ligand | Oligoglycosylceramides | Human erythrocytes | GalNAc(b1-3)GalNAc(b1-3)Gal(a1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 2358461 |
| Escherichia coli | Type 1-fimbriae | unnamed ligand | Oligosaccharides | Urine | Man(a1-3)Man(a1-6)Man | Binding | 16564136 |
| Clostridium difficile | Toxin A | unnamed ligand | Oligosaccharides | Human colonic cells | GalNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Norovirus | Unknown | Blood group B antigen | Oligosaccharides | Saliva | Gal(a1-3)[Fuc(a1-2)]Gal | Binding | 18701592 |
| Norovirus | Unknown | Blood group A antigen | Oligosaccharides | Saliva | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)GlcNAc | Binding | 18701592 |
| Clostridium difficile | C-terminal domain of toxin A molecules | unnamed ligand | Oligosaccharides | Human colonic cells | GalNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Norovirus | Unknown | Blood group A antigen | Oligosaccharides | Human saliva | GalNAc(a1-3)[Fuc(a1-2)]Gal(b1-3)GlcNAc | Binding | 16707048 |
| Neisseria gonorrhoeae | Adhesins | unnamed ligand | Oligosaccharides | Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva | Gal(b1-4)GlcNAc(b1-4)Gal(b1-4)Glc | Binding | 2115881 |
| Neisseria gonorrhoeae | 18-kDa proteins | unnamed ligand | Oligosaccharides | Mucos membranes of the genitourinary tract/rectum/oropharynx/conjunctiva | Gal(b1-4)GlcNAc(b1-4)Gal(b1-4)Glc | Binding | 2115881 |
| Influenza virus | SNA lectins | Minor NeuAcα6-containing molecules | Glycoconjugates | Human leukocytes | Binding | 11030743 | |
| Escherichia coli | Type 1-fimbriae | Glycoside p-nitrophenyl alpha-D-mannopyranoside | Glycoconjugates | Patient with urinary tract infection | Binding | 6138149 | |
| Adenovirus | Fibre proteins | HSA glycoconjugates | Glycoproteins | Human corneal epithelial(HEC) cells | Binding | 15678425 | |
| Entamoeba histolytica | Transmembrane heavy subunit (Hgl; 170-kDa) disulfide linked to a GPI-anchored light subunit (Lgl; 31-to 35-kDa). | β-2 and β-7 integrins | Glycoproteins | Intestinal cells | Binding | 15322032 | |
| Sporothrix schenckii | Yeast cells and conidia | Fibronectin | Glycoproteins | Extracellular matrix (ECM) | Binding | 11598061 | |
| Paracoccidioides brasiliensis | Adhesins | Fibronectin | Glycoproteins | Human type II alveolar cells (A549) | Binding | 18083324 | |
| Streptococcus pyogenes | Protein F (Antigen I/II) | Fibronectin | Glycoproteins | Respiratory endothelial cells | Binding | 10341176 | |
| Streptococcus pyogenes | Protein F (Antigen I/II) | Fibronectin | Glycoproteins | Respiratory epithelial cells | Binding | 1385871 |
