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Pathogen Adherence to Carbohydrate Database (PACDB)
PACDB provides the information on pathogens (e.g. bacteria, fungus, toxin and virus) adhering to carbohydrates expressed on the cell surface of host animals or plants.
| Source | Last Updated |
|---|---|
| Pathogen Adherence to Carbohydrate Database (PACDB) | June 1, 2016 |
| Species | Pathogen Adherence Molecule ▲ | Ligand Name | Ligand Feature | Target Source | Glycan Sequence | Binding | PubMed ID |
|---|---|---|---|---|---|---|---|
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylgalactosamine | Monosaccharides | Intestinal epithelial cells (T84) | GalNAc | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Galactose | Monosaccharides | Intestinal epithelial cells (T84) | Gal | Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | N-Acetylglucosamine | Monosaccharides | Intestinal epithelial cells (T84) | GlcNAc | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Mannose | Monosaccharides | Intestinal epithelial cells (T84) | Man | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Glucose | Monosaccharides | Intestinal epithelial cells (T84) | Glc | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (16S) | Fucose | Monosaccharides | Intestinal epithelial cells (T84) | Fuc | Not Binding | 17156748 |
| Clostridium botulinum | Botulinum neurotoxin (type C) | GD1b | Disialoglycosphingolipids | Presynaptic neuronal cells | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Clostridium botulinum | Botulinum neurotoxin (type C) | GT1b | Trisialoglycosphingolipids | Presynaptic neuronal cells | NeuAc(a2-3)Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-8)NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 18242046 |
| Clostridium botulinum | Botulinum neurotoxin (type D) | Phosphatidylethanolamine (PE) | Non-glycosylated Lipids | Presynaptic neuronal cells | Binding | 18242046 | |
| Clostridium difficile | C-terminal domain of toxin A molecules | unnamed ligand | Oligosaccharides | Human colonic cells | Gal(a1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Clostridium difficile | C-terminal domain of toxin A molecules | unnamed ligand | Oligosaccharides | Human colonic cells | GalNAc(b1-3)Gal(b1-4)GlcNAc | Binding | 12507507 |
| Vibrio cholerae | CBP (chitin-binding proteins) 36-kDa and 53-kDa | N-Acetylglucosamine | Monosaccharides | GlcNAc | Binding | 10049907 | |
| Vibrio alginolyticus | CBP (chitin-binding proteins) 53-kDa | N-Acetylglucosamine | Monosaccharides | GlcNAc | Binding | 10049907 | |
| Vibrio harveyi | CBP (chitin-binding proteins) 53-kDa | N-Acetylglucosamine | Monosaccharides | GlcNAc | Binding | 10049907 | |
| Trypanosoma cruzi | CBPs (carbohydrate-binding proteins) | High mannose glycans containig the Manα1-2Manα1-6Manα1-6 structure | Saccharides | Man(a1-2)Man(a1-6)Man(a1-6) | Binding | 11555616 | |
| Streptococcus pneumoniae | CBPs (choline-binding proteins) | nLc4Cer (Neolactotetraosylceramide; Paragloboside) | Oligoglycosylceramides | Cytokine-activated cells | Gal(b1-4)GlcNAc(b1-3)Gal(b1-4)Glc(b1-1)Cer | Binding | 12640357 |
| Streptococcus pneumoniae | CBPs (choline-binding proteins) | Sialic acid | Monosaccharides | Cytokine-activated cells | Binding | 12640357 | |
| Escherichia coli | CFA/1 | Sialic acid (α2,8) | Saccharides | Intestinal cells | NeuAc(a2-8) | Binding | 16564136 |
| Bordetella pertussis | CRD (carbohydrate recognition domain) of Fha (Filamentous Hemagglutinin) | Lactosylceramide (Lactocerebroside) | Diosylceramides | Respiratory ciliated cells, Alveolar macrophages | Gal(b1-4)Glc(b1-1)Cer | Binding | 8514379 |
| Escherichia coli | CS3 (coli surface 3)-fimbriae | GM1 | Monosialoglycosphingolipids | Intestinal epithelium, Rabbit intestine | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7822033 |
| Escherichia coli | CS3 (coli surface 3)-fimbriae | GM2(NeuAc) | Monosialoglycosphingolipids | Intestinal epithelium, Rabbit intestine | GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 7822033 |
| Escherichia coli | CS3 (coli surface 3)-fimbriae | Asialo GM1 (Gangliotetraosylceramide; Gg4; GA1) | Oligoglycosylceramides | Intestinal epithelium, Rabbit intestine | Gal(b1-3)GalNAc(b1-4)Gal(b1-4)Glc(b1-1)Cer | Binding | 7822033 |
| Streptococcus pneumoniae | CTB-PsaA pentamers | GM1 | Monosialoglycosphingolipids | Serum, Saliva, Nasal/bronchial wash samples | Gal(b1-3)GalNAc(b1-4)[NeuAc(a2-3)]Gal(b1-4)Glc(b1-1)Cer | Binding | 15358234 |
| Streptococcus gordonii | Ca2+-independent lectins | Hs antigen | Glycoproteins | NeuAc(a2-3)Gal(b1-4)Glc-HSA | Binding | 9393794 | |
| Streptococcus gordonii | Ca2+-independent lectins | Fetuin | Glycoproteins | Binding | 9393794 |
