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MIRAGE
Presynaptic depolarization and calcium channel opening

Summary
Organism
Homo sapiens (human)
Reactome
R-HSA-112308
PubChem
R-HSA-112308
Description
  • Action potentials occur in electrically excitable cells such as neurons, muscles, and endocrine cells. They are initiated by transient opening of voltage dependent sodium channels, causing a rapid, large depolarization of membrane potentials that spread along the axon membrane.
    The action potential travels down the axon and reaches the presynaptic terminal depolarizing the membrane in the pre synaptic terminal. The depolarization causes the voltage gated Ca2+ channels to open allowing the influx of Ca2+ that signals the release of neurotransmitter into the synaptic cleft.
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018
If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026