GlyCosmos Portal

Submissions

Cross-presentation of particulate exogenous antigens (phagosomes)

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1236973

PubChem

R-HSA-1236973

Description

Dendritic cells (DCs) take up and process exogenous particulate or cell-associated antigens such as microbes or tumor cells for MHC-I cross-presentation. Particulate antigens have been reported to be more efficiently cross-presented than soluble antigens by DCs (Khor et al. 2008). Particulate antigens are internalized by phagosomes. There are two established models that explain the mechanism by which exogenous particulate antigens are presented through MHC I; the cytosolic pathway where internalized antigens are somehow translocated from phagosomes into cytosol for proteasomal degradation and the vacuolar pathway (Lin et al. 2008, Amigorena et al. 2010).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 4** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P04839	NADPH oxidase 2	CYBB NOX2	view
P06756	Integrin alpha-V	ITGAV MSK8 VNRA VTNR	view
P16671	Platelet glycoprotein 4	CD36 GP3B GP4	view
P18084	Integrin beta-5	ITGB5	view

If you want to check the location of a particular molecule, you can do so by clicking on the "Switching Highlight" button on the page you have navigated to by clicking on "view".

About Release Notes Help Feedback

Click here to visit the beta site.