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Integrin beta-5

Summary

UniProt ID: P18084
Gene Symbol: ITGB5
Gene ID: 3693
Organism: Homo sapiens (human)

External Links

GlycoProtDB

GPDB0011579

GlyConnect

Integrin beta-5

GlyGen

P18084

PubChem

P18084

RaftProt

P18084

Re-Glyco

P18084

Annotation

Keyword: 3D-structure Calcium Cell adhesion Cell membrane Disulfide bond EGF-like domain Glycoprotein Host cell receptor for virus entry Host-virus interaction Integrin Magnesium Metal-binding Phosphoprotein Proteomics identification Reference proteome Repeat Signal Transmembrane helix

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	Reference
cell-matrix adhesion	NAS	PMID
cell-matrix adhesion	IMP	PMID
cell-matrix adhesion	IBA	GO_REF
cell-matrix adhesion	IEA	GO_REF
transforming growth factor beta receptor signaling pathway	IMP	PMID

GO Hierarchy

biological process

cellular process [inference]

cell adhesion [inference]

cell-substrate adhesion [inference]

cell-matrix adhesion

cell adhesion mediated by integrin

cell-cell adhesion

epithelial cell-cell adhesion

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

actin filament-based process [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

cell motility [inference]

cell migration

wound healing, spreading of cells [inference]

wound healing, spreading of epidermal cells

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization [inference]

stress fiber assembly

cellular component assembly [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

contractile actin filament bundle assembly [inference]

stress fiber assembly

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

endodermal cell differentiation

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein serine/threonine kinase signaling pathway [inference]

transforming growth factor beta receptor superfamily signaling pathway [inference]

transforming growth factor beta receptor signaling pathway

integrin-mediated signaling pathway

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	Reference
plasma membrane	TAS	Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome Reactome
plasma membrane	IEA	GO_REF
focal adhesion	IBA	GO_REF
focal adhesion	HDA	PMID
integrin complex	IBA	GO_REF

GO Hierarchy

cellular component

protein-containing complex [inference]

signaling receptor complex

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

protein complex involved in cell adhesion [inference]

integrin complex

integrin alphav-beta5 complex

membrane protein complex [inference]

plasma membrane protein complex [inference]

plasma membrane signaling receptor complex [inference]

integrin complex

integrin alphav-beta5 complex

cellular anatomical structure [inference]

cell surface

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endocytic vesicle [inference]

phagocytic vesicle

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	Reference
virus receptor activity
integrin binding	IBA	GO_REF
metal ion binding

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

signaling receptor binding [inference]

integrin binding

cell adhesion molecule binding [inference]

integrin binding

exogenous protein binding [inference]

virus receptor activity

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

protein-containing complex binding [inference]

integrin binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MPRAPAPLYACLLGLCALLPRLAGLNICTSGSATSCEECLLIHPKCAWCSKEDFGSPRSITSRCDLRANLVKNGCGGEIESPASSFHVLRSLPLSSKGSGSAGWDVIQMTPQEIAVNLRPGDKTTFQLQVRQVEDYPVDLYYLMDLSLSMKDDLDNIRSLGTKLAEEMRKLTSNFRLGFGSFVDKDISPFSYTAPRYQTNPCIGYKLFPNCVPSFGFRHLLPLTDRVDSFNEEVRKQRVSRNRDAPEGGFDAVLQAAVCKEKIGWRKDALHLLVFTTDDVPHIALDGKLGGLVQPHDGQCHLNEANEYTASNQMDYPSLALLGEKLAENNINLIFAVTKNHYMLYKNFTALIPGTTVEILDGDSKNIIQLIINAYNSIRSKVELSVWDQPEDLNLFFTATCQDGVSYPGQRKCEGLKIGDTASFEVSLEARSCPSRHTEHVFALRPVGFRDSLEVGVTYNCTCGCSVGLEPNSARCNGSGTYVCGLCECSPGYLGTRCECQDGENQSVYQNLCREAEGKPLCSGRGDCSCNQCSCFESEFGKIYGPFCECDNFSCARNKGVLCSGHGECHCGECKCHAGYIGDNCNCSTDISTCRGRDGQICSERGHCLCGQCQCTEPGAFGEMCEKCPTCPDACSTKRDCVECLLLHSGKPDNQTCHSLCRDEVITWVDTIVKDDQEAVLCFYKTAKDCVMMFTYVELPSGKSNLTVLREPECGNTPNAMTILLAVVGSILLVGLALLAIWKLLVTIHDRREFAKFQSERSRARYEMASNPLYRKPISTHTVDFTFNKFNKSYNGTVD

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	Description	PubMed ID	GlyTouCan ID	Source
197		23584533	G57321FI	GlyGen
199		23584533	G57321FI	GlyGen
347	N-linked (GlcNAc...) asparagine	29741879 37074911	G51653BI G83460ZZ G59626AS G48584BU G70101JE G80920RR G62765YT G10486CT G28541PG G31852PQ G39188ZX G41247ZX G02815KT G06110VR	UniProt GlyGen GlyConnect
460	N-linked (GlcNAc...) asparagine			UniProt GlyGen
477	N-linked (GlcNAc...) asparagine	37074911	G45395BF G80920RR G62765YT G41247ZX G02815KT	UniProt GlyGen
505	N-linked (GlcNAc...) asparagine		G80920RR	UniProt GlyGen
552	N-linked (GlcNAc...) asparagine		G83460ZZ	UniProt GlyGen
586	N-linked (GlcNAc...) asparagine	23090970 24190977 29741879 37074911	G15664MX G72747WU G59626AS G80920RR G01485JJ G90659AW G62765YT G64527OM G10486CT G05049YU G28541PG G05724UK G31852PQ G23719VF G39446WN G39188ZX G41247ZX G57776ZU G02815KT G57317CE	GlycoProtDB UniProt GlyGen GlyConnect
654	N-linked (GlcNAc...) asparagine	23090970 24190977	G62765YT	UniProt GlyGen
705	N-linked (GlcNAc...) asparagine		G28541PG	UniProt GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

Displaying **all 7** entries
Pathway Name	Organism
Cross-presentation of particulate exogenous antigens (phagosomes)	Homo sapiens
ECM proteoglycans	Homo sapiens
Integrin cell surface interactions	Homo sapiens
Molecules associated with elastic fibres	Homo sapiens
Smooth Muscle Contraction	Homo sapiens
Syndecan interactions	Homo sapiens
TGF-beta receptor signaling activates SMADs	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

International Collaboration

Acknowledgements