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Endosomal/Vacuolar pathway

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-1236977

PubChem

R-HSA-1236977

Description

Some antigens are cross-presented through a vacuolar mechanism that involves generation of antigenic peptides and their loading on to MHC-I molecules within the endosomal compartment in a proteasome and TAP-independent manner. Antigens within the endosome are processed by cathepsin S and other proteases into antigenic peptides. Loading of these peptides onto MHC-I molecules occurs directly within early and late endosomal compartments. Why certain antigens are cross-presented exclusively by the cytosolic pathway while others use the vacuolar pathway is unknown. It may be because some epitopes cannot be generated by endosomal proteolysis, or are completely destroyed. Alternatively, the physical form of the antigen may influence its accessibility to the endosomal or vacuolar pathways (Shen et al. 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 12 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O60911	Cathepsin L2	CATL2 CTSL2 CTSU CTSV UNQ268/PRO305	view
P01889	HLA class I histocompatibility antigen, B alpha chain	HLA-B HLAB	view
P01893	Putative HLA class I histocompatibility antigen, alpha chain H	HLA-H HLAH	view
P04439	HLA class I histocompatibility antigen, A alpha chain	HLA-A HLAA	view
P07711	Procathepsin L	CTSL CTSL1 hCG_30369	view
P10321	HLA class I histocompatibility antigen, C alpha chain	HLA HLA-C HLA-Cw HLAC	view
P13747	HLA class I histocompatibility antigen, alpha chain E	HLA-6.2 HLA-E HLAE	view
P17693	HLA class I histocompatibility antigen, alpha chain G	HLA-6.0 HLA-G HLAG	view
P25774	Cathepsin S	CTSS	view
P30511	HLA class I histocompatibility antigen, alpha chain F	HLA-5.4 HLA-F HLAF	view

Displaying 1 entry
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_005335	P61769	Beta-2-microglobulin [Cleaved into: Beta-2-microglobulin form pI 5.3]	view

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