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MTOR signalling

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-165159

PubChem

R-HSA-165159

Description

Mammalian target of rapamycin (mTOR) is a highly conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Control of mTOR activity is critical for the cell since its dysregulation leads to cancer, metabolic disease, and diabetes (Laplante & Sabatini 2012). In cells, mTOR exists as two structurally distinct complexes termed mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2), each one with specificity for different sets of effectors (reviewed in Jhanwar-Uniyal et al. 2019). mTORC1 couples energy and nutrient abundance to cell growth and proliferation by balancing anabolic (protein synthesis and nutrient storage) and catabolic (autophagy and utilization of energy stores) processes. mTORC2 is responsive to growth factor signaling (reviewed in Jhanwar-Uniyal et al. 2019). mTORC1 and mTORC2 cross-talk through AKT and S6K (reviewed in Jhanwar-Uniyal et al. 2019). Rapamycin, the inhibitor of mTOR, inhibits only mTORC1, as the RICTOR subunit of mTORC2 masks the rapamycin-interacting domain of MTOR in mTORC2 (reviewed in Simcox and Lamming 2023).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 18 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
P00558	Phosphoglycerate kinase 1	MIG10 OK/SW-cl.110 PGK1 PGKA	view
P31749	RAC-alpha serine/threonine-protein kinase	AKT1 PKB RAC	view
P31751	RAC-beta serine/threonine-protein kinase	AKT2	view
P42345	Serine/threonine-protein kinase mTOR	FRAP FRAP1 FRAP2 MTOR RAFT1 RAPT1	view
Q15382	GTP-binding protein Rheb	RHEB RHEB2	view
Q5VZM2	Ras-related GTP-binding protein B	RRAGB	view
Q8N122	Regulatory-associated protein of mTOR	KIAA1303 RAPTOR RPTOR	view
Q8NBW4	Neutral amino acid transporter 9	SLC38A9 URLC11	view
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	CAGH26 KIAA1460 TNRC6 TNRC6A	view
Q96B36	Proline-rich AKT1 substrate 1	AKT1S1 PRAS40	view

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