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Initial triggering of complement

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-166663

PubChem

R-HSA-166663

Description

Complement activation is due to a cascade of proteolytic steps, performed by serine protease domains in some of the components. Three different pathways of activation are distinguished triggered by target-bound antibody (the classical pathway); microbial polysaccharide structures (the lectin pathway); or recognition of other "foreign" surface structures (the alternative pathway) by C3b. All three merge in the pivotal activation of C3 and, subsequently, of C5 by highly specific enzymatic complexes, the so-called C3/C5 convertases. A complement system with three C3 activation pathways and a common lytic pathway is found only in jawed vertebrates.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 28 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00602	Ficolin-1	FCN1 FCNM	view
O75636	Ficolin-3	FCN3 FCNH HAKA1 UNQ172 hCG_19629	view
P00736	Complement C1r subcomponent	C1R	view
P01593	Immunoglobulin kappa variable 1D-33	IGKV1D-33	view
P01705	Immunoglobulin lambda variable 2-23	IGLV2-23	view
P01824	Immunoglobulin heavy variable 4-39	IGHV4-39	view
P01834	Immunoglobulin kappa constant	IGKC	view
P01857	Immunoglobulin heavy constant gamma 1	IGHG1	view
P01859	Immunoglobulin heavy constant gamma 2	IGHG2	view
P01860	Immunoglobulin heavy constant gamma 3	IGHG3	view

Displaying **all 8** entries
GlyCosmos Lectin	UniProt ID	Lectin Name	Pathway Viewer
GL_000384	O00602	Ficolin-1	view
GL_000393	O75636	Ficolin-3	view
GL_001413	P0C0L5	Complement C4-B	view
GL_002010	Q15485	Ficolin-2	view
GL_002337	P0DTC2	Spike glycoprotein	view
GL_002341	P11226	Mannose-binding protein C	view
GL_002404	Q9BWP8	Collectin-11	view
GL_004621	Q9Y6Z7	Collectin-10	view

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