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Formation of HIV-1 elongation complex containing HIV-1 Tat

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-167200

PubChem

R-HSA-167200

Description

This HIV-1 event was inferred from the corresponding human RNA Poll II transcription event in Reactome. The details relevant to HIV-1 are described below. For a more detailed description of the general mechanism, see the link to the corresponding RNA Pol II transcription event below. The formation of the HIV-1 elongation complex involves Tat mediated recruitment of P-TEFb(Cyclin T1:Cdk9) to the TAR sequence (Wei et al, 1998) and P-TEFb(Cyclin T1:Cdk9) mediated phosphorylation of the RNA Pol II CTD as well as the negative transcriptional elongation factors DSIF and NELF (Herrmann, 1995; Ivanov et al. 2000; Fujinaga et al. 2004; Zhou et al., 2004).

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 19 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00267	Transcription elongation factor SPT5	SPT5 SPT5H SUPT5H	view
O15514	DNA-directed RNA polymerase II subunit RPB4	POLR2D	view
O60563	Cyclin-T1	CCNT1	view
P13984	General transcription factor IIF subunit 2	GTF2F2 RAP30	view
P18615	Negative elongation factor E	NELFE RD RDBP	view
P24928	DNA-directed RNA polymerase II subunit RPB1	POLR2 POLR2A	view
P30876	DNA-directed RNA polymerase II subunit RPB2	POLR2B	view
P32780	General transcription factor IIH subunit 1	BTF2 GTF2H1	view
P35269	General transcription factor IIF subunit 1	GTF2F1 RAP74	view
P50613	Cyclin-dependent kinase 7	CAK CAK1 CDK7 CDKN7 MO15 STK1	view

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