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DNA-directed RNA polymerase II subunit RPB1

Summary

UniProt ID

P24928

Gene Symbol

POLR2
POLR2A

Gene ID

5430

Organism

Homo sapiens (human)

External Links

GlyGen: P24928
PubChem: P24928
The Human Metabolome Database: HMDBP00739
The O-GlcNAc Database: P24928
O-GlcNAcAtlas: P24928
Re-Glyco: P24928

Annotation

Keyword: 3D-structure Acetylation Alternative splicing Chromosome Cytoplasm DNA-binding DNA-directed RNA polymerase Disease variant Host-virus interaction Hydrolase Intellectual disability Isopeptide bond Magnesium Metal-binding Methylation Nucleus Phosphoprotein Proteomics identification RNA-directed RNA polymerase Reference proteome Repeat Ubl conjugation Zinc

Gene Ontology (GO)

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GO Term	Evidence Code	Reference
DNA-templated transcription termination	IMP	PMID
DNA-templated transcription termination	IEA	GO_REF
regulation of transcription, DNA-templated	NAS	PMID
regulation of DNA-templated transcription	NAS	PMID
transcription by RNA polymerase II	NAS	PMID

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mRNA metabolic process [inference]

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

mRNA transcription by RNA polymerase II

mRNA transcription [inference]

mRNA transcription by RNA polymerase II

DNA-templated transcription termination

DNA-templated transcription elongation [inference]

transcription elongation by RNA polymerase II

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of RNA splicing [inference]

positive regulation of RNA splicing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of RNA splicing [inference]

positive regulation of RNA splicing

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of transcription, DNA-templated

regulation of RNA splicing [inference]

positive regulation of RNA splicing

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of RNA splicing

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GO Term	Evidence Code	Reference
magnesium ion binding	IDA	PMID
magnesium ion binding	IEA	GO_REF
DNA binding	NAS	PMID
DNA binding	TAS	PMID
DNA binding	IEA	GO_REF

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

binding [inference]

nucleic acid binding [inference]

chromatin binding [inference]

promoter-specific chromatin binding

protein binding [inference]

enzyme binding [inference]

kinase binding

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

magnesium ion binding

transition metal ion binding [inference]

zinc ion binding

extracellular matrix binding [inference]

microfibril binding

Gene Ontology information from UniProt.

Annotation information from UniProt.

Sequence

MHGGGPPSGDSACPLRTIKRVQFGVLSPDELKRMSVTEGGIKYPETTEGGRPKLGGLMDPRQGVIERTGRCQTCAGNMTECPGHFGHIELAKPVFHVGFLVKTMKVLRCVCFFCSKLLVDSNNPKIKDILAKSKGQPKKRLTHVYDLCKGKNICEGGEEMDNKFGVEQPEGDEDLTKEKGHGGCGRYQPRIRRSGLELYAEWKHVNEDSQEKKILLSPERVHEIFKRISDEECFVLGMEPRYARPEWMIVTVLPVPPLSVRPAVVMQGSARNQDDLTHKLADIVKINNQLRRNEQNGAAAHVIAEDVKLLQFHVATMVDNELPGLPRAMQKSGRPLKSLKQRLKGKEGRVRGNLMGKRVDFSARTVITPDPNLSIDQVGVPRSIAANMTFAEIVTPFNIDRLQELVRRGNSQYPGAKYIIRDNGDRIDLRFHPKPSDLHLQTGYKVERHMCDGDIVIFNRQPTLHKMSMMGHRVRILPWSTFRLNLSVTTPYNADFDGDEMNLHLPQSLETRAEIQELAMVPRMIVTPQSNRPVMGIVQDTLTAVRKFTKRDVFLERGEVMNLLMFLSTWDGKVPQPAILKPRPLWTGKQIFSLIIPGHINCIRTHSTHPDDEDSGPYKHISPGDTKVVVENGELIMGILCKKSLGTSAGSLVHISYLEMGHDITRLFYSNIQTVINNWLLIEGHTIGIGDSIADSKTYQDIQNTIKKAKQDVIEVIEKAHNNELEPTPGNTLRQTFENQVNRILNDARDKTGSSAQKSLSEYNNFKSMVVSGAKGSKINISQVIAVVGQQNVEGKRIPFGFKHRTLPHFIKDDYGPESRGFVENSYLAGLTPTEFFFHAMGGREGLIDTAVKTAETGYIQRRLIKSMESVMVKYDATVRNSINQVVQLRYGEDGLAGESVEFQNLATLKPSNKAFEKKFRFDYTNERALRRTLQEDLVKDVLSNAHIQNELEREFERMREDREVLRVIFPTGDSKVVLPCNLLRMIWNAQKIFHINPRLPSDLHPIKVVEGVKELSKKLVIVNGDDPLSRQAQENATLLFNIHLRSTLCSRRMAEEFRLSGEAFDWLLGEIESKFNQAIAHPGEMVGALAAQSLGEPATQMTLNTFHYAGVSAKNVTLGVPRLKELINISKKPKTPSLTVFLLGQSARDAERAKDILCRLEHTTLRKVTANTAIYYDPNPQSTVVAEDQEWVNVYYEMPDFDVARISPWLLRVELDRKHMTDRKLTMEQIAEKINAGFGDDLNCIFNDDNAEKLVLRIRIMNSDENKMQEEEEVVDKMDDDVFLRCIESNMLTDMTLQGIEQISKVYMHLPQTDNKKKIIITEDGEFKALQEWILETDGVSLMRVLSEKDVDPVRTTSNDIVEIFTVLGIEAVRKALERELYHVISFDGSYVNYRHLALLCDTMTCRGHLMAITRHGVNRQDTGPLMKCSFEETVDVLMEAAAHGESDPMKGVSENIMLGQLAPAGTGCFDLLLDAEKCKYGMEIPTNIPGLGAAGPTGMFFGSAPSPMGGISPAMTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAASDASGFSPGYSPAWSPTPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYTPQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPNYTPTSPSYSPTSPSYSPTSPNYTPTSPNYSPTSPSYSPTSPSYSPTSPSYSPSSPRYTPQSPTYTPSSPSYSPSSPSYSPTSPKYTPTSPSYSPSSPEYTPTSPKYSPTSPKYSPTSPKYSPTSPTYSPTTPKYSPTSPTYSPTSPVYTPTSPKYSPTSPTYSPTSPKYSPTSPTYSPTSPKGSTYSPTSPGYSPTSPTYSLTSPAISPDDSDEEN

N : N-glycosylation Site
___ : Potential Sequon

Glycosylation Sites

Displaying **all 10** entries
Position	PubMed ID	GlyTouCan ID	Source
728			GlyGen
1116		G41247ZX	GlyGen
1499			GlyGen
1525			GlyGen
1534	22371499 22605332 26807597 26853435 29351928 34019948 34725712 37217939 37689115 38665916	G49108TO	The O-GlcNAc Database
1568			GlyGen
1619	22371499 22605332 26807597 26853435 29351928 34019948 34725712 37217939 37689115 38665916	G49108TO	The O-GlcNAc Database
1621	22371499 22605332 26807597 26853435 29351928 34019948 34725712 37217939 37689115 38665916	G49108TO	The O-GlcNAc Database
1822		G49108TO	GlyGen
1889		G49108TO	GlyGen

Feature

: Glycosylation Site from GlyGen
: Glycosylation Site from UniProt

Pathway

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Pathway Name	Organism
Abortive elongation of HIV-1 transcript in the absence of Tat	Homo sapiens
Activation of anterior HOX genes in hindbrain development during early embryogenesis	Homo sapiens
Dual incision in TC-NER	Homo sapiens
Estrogen-dependent gene expression	Homo sapiens
FGFR2 alternative splicing	Homo sapiens
Formation of HIV elongation complex in the absence of HIV Tat	Homo sapiens
Formation of HIV-1 elongation complex containing HIV-1 Tat	Homo sapiens
Formation of RNA Pol II elongation complex	Homo sapiens
Formation of TC-NER Pre-Incision Complex	Homo sapiens
Formation of the Early Elongation Complex	Homo sapiens

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

Annotation

International Collaboration

Acknowledgements