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Tat-mediated HIV elongation arrest and recovery

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-167243

PubChem

R-HSA-167243

Description

RNA Pol II arrest is believed to be a result of irreversible backsliding of the enzyme by ~7-14 nucleotides. TFIIS reactivates arrested RNA Pol II by promoting the excision of nascent transcript ~7-14 nucleotides upstream of the 3' end.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying entries **1 - 10** of 15 in total

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UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O00267	Transcription elongation factor SPT5	SPT5 SPT5H SUPT5H	view
O15514	DNA-directed RNA polymerase II subunit RPB4	POLR2D	view
O60563	Cyclin-T1	CCNT1	view
P13984	General transcription factor IIF subunit 2	GTF2F2 RAP30	view
P18615	Negative elongation factor E	NELFE RD RDBP	view
P24928	DNA-directed RNA polymerase II subunit RPB1	POLR2 POLR2A	view
P30876	DNA-directed RNA polymerase II subunit RPB2	POLR2B	view
P35269	General transcription factor IIF subunit 1	GTF2F1 RAP74	view
Q08945	FACT complex subunit SSRP1	FACT80 SSRP1	view
Q14241	Elongin-A	ELOA MSTP059 TCEB3	view

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