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Nef Mediated CD4 Down-regulation

Summary

Organism

Homo sapiens (human)

Reactome

R-HSA-167590

PubChem

R-HSA-167590

Description

The presence of Nef accelerates endocytosis and lysosomal degradation of the transmembrane glycoprotein CD4. CD4 has its own internalization motif, though this motif is normally concealed by CD4 interaction with Lck, a tyrosine kinase. Nef is known to disrupt this interaction and then facilitate a cascade of protein interactions that ultimately result in the degradation of internalized CD4 protein. The final set of protein interactions that direct Nef to the beta-subunit of the COPI coatomers are at this time unclear.

A benefit for the virus from CD4 down-modulation is abolition of interaction between the receptor and the Env protein of the budding virus, which likely increases HIV release from infected cell as well as infectivity of viral particles.

Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.

SPV: a JavaScript Signaling Pathway Visualizer, Bioinformatics, 2018

Displaying **all 5** entries
UniProt ID	Protein Name	Gene Symbol	Pathway Viewer
O94973	AP-2 complex subunit alpha-2	ADTAB AP2A2 CLAPA2 HIP9 HYPJ KIAA0899	view
O95782	AP-2 complex subunit alpha-1	ADTAA AP2A1 CLAPA1	view
P01730	T-cell surface glycoprotein CD4	CD4	view
P63010	AP-2 complex subunit beta	ADTB2 AP2B1 CLAPB1	view
Q96CW1	AP-2 complex subunit mu	AP2M1 CLAPM1 KIAA0109	view

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