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MIRAGE
T-cell surface glycoprotein CD4

Summary
UniProt ID
P01730
Gene Symbol
  • CD4
Gene ID
920
Organism
Homo sapiens (human)
GlyConnect
GlyGen
P01730
PubChem
P01730
Re-Glyco
P01730
Annotation
Keyword
  • 3D-structure
  • Adaptive immunity
  • Cell membrane
  • Direct protein sequencing
  • Disulfide bond
  • Glycoprotein
  • Host cell receptor for virus entry
  • Host-virus interaction
  • Immunoglobulin domain
  • Palmitate
  • Phosphoprotein
  • Reference proteome
  • Repeat
  • Signal
  • Transmembrane helix
Gene Ontology (GO)
Displaying all 8 entries
GO Term
plasma membrane
T cell receptor complex
early endosome
endoplasmic reticulum lumen
endoplasmic reticulum membrane
external side of plasma membrane
membrane raft
clathrin-coated endocytic vesicle membrane
Subcellular Location(GO Annotation)

Subcellular in which this glycoprotein is expressed are highlighted in blue.

Annotation information from UniProt.
Sequence
MNRGVPFRHLLLVLQLALLPAATQGKKVVLGKKGDTVELTCTASQKKSIQFHWKNSNQIKILGNQGSFLTKGPSKLNDRADSRRSLWDQGNFPLIIKNLKIEDSDTYICEVEDQKEEVQLLVFGLTANSDTHLLQGQSLTLTLESPPGSSPSVQCRSPRGKNIQGGKTLSVSQLELQDSGTWTCTVLQNQKKVEFKIDIVVLAFQKASSIVYKKEGEQVEFSFPLAFTVEKLTGSGELWWQAERASSSKSWITFDLKNKEVSVKRVTQDPKLQMGKKLPLHLTLPQALPQYAGSGNLTLALEAKTGKLHQEVNLVVMRATQLQKNLTCEVWGPTSPKLMLSLKLENKEAKVSKREKAVWVLNPEAGMWQCLLSDSGQVLLESNIKVLPTWSTPVQPMALIVLGGVAGLLLFIGLGIFFCVRCRHRRRQAERMSQIKRLLSEKKTCQCPHRFQKTCSPI
  • N : N-glycosylation Site
  • ___ : Potential Sequon
Glycosylation Sites
Displaying all 5 entries
Position Description PubMed ID GlyTouCan ID Source
98
296 N-linked (GlcNAc...) asparagine
325 N-linked (GlcNAc...) asparagine
334
Feature
  • ProtVista GlyGen : Glycosylation Site from GlyGen
  • ProtVista UniProt : Glycosylation Site from UniProt
Pathway
Displaying entries 1 - 10 of 12 in total
Pathway Name Organism
Alpha-defensins Homo sapiens
Binding and entry of HIV virion Homo sapiens
Cargo recognition for clathrin-mediated endocytosis Homo sapiens
Clathrin-mediated endocytosis Homo sapiens
Downstream TCR signaling Homo sapiens
Generation of second messenger molecules Homo sapiens
Nef Mediated CD4 Down-regulation Homo sapiens
Other interleukin signaling Homo sapiens
PD-1 signaling Homo sapiens
Phosphorylation of CD3 and TCR zeta chains Homo sapiens
Disease
Displaying 1 entry
DO ID Disease Name Source
DOID:0112277 immunodeficiency 79
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 7, 2025