FGFR1c and Klotho ligand binding and activation

Summary
Organism
Homo sapiens (human)
Reactome
R-HSA-190374
PubChem
R-HSA-190374
Description
  • FGF23 is a member of the endocrine subfamily of FGFs. It is produced in bone tissue and regulates kidney functions. Klotho is essential for endogenous FGF23 function as it converts FGFR1c into a specific FGF23 receptor.
Click on a node on the pathway to see its details. Glycoproteins are marked with a glycoprotein icon in their name.
Displaying 1 entry
UniProt ID Protein Name Gene Symbol Pathway Viewer
Q9GZV9 Fibroblast growth factor 23
  • FGF23
  • HYPF
  • UNQ3027/PRO9828
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International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: April 6, 2026